Taïeb A
Laboratoire d'Immunologie/CNRS URA 1456, Université de Bordeaux II, France.
Pathol Biol (Paris). 1992 Feb;40(2):85-93.
This review summarizes recent data on the keratinocyte, the major cell type in the epidermis. A two-state model is proposed: in the "resting" state, the keratinocyte is committed to a program of terminal differentiation focusing on production of an efficient barrier, the stratum corneum, and of the epidermal basement membrane; the activated state, first discovered in cell culture studies, occurs in vivo during epidermal wound healing and inflammatory skin diseases.
本综述总结了关于角质形成细胞（表皮中的主要细胞类型）的最新数据。提出了一种双态模型：在“静止”状态下，角质形成细胞致力于一个终末分化程序，重点是产生高效的屏障——角质层和表皮基底膜；激活状态最早在细胞培养研究中发现，在表皮伤口愈合和炎症性皮肤病期间在体内出现。
