Sato M, Ahnen D J
Department of Surgery, Saint Marianna University School of Medicine, Kawasaki, Japan.
Anat Rec. 1992 Jul;233(3):409-14. doi: 10.1002/ar.1092330308.
The location of stem cells and the direction of colonocyte migration in the normal rat colonic crypt were investigated using a serial bromodeoxyuridine (BrdU) and [3H]thymidine labeling protocol. The results demonstrate that in the distal colon the stem cells are located in the crypt base and that cells migrate up toward the luminal surface. In the proximal colon, however, the stem cells are located in the midcrypt, and the colonocytes migrate in two directions, up toward the luminal surface and down toward the crypt base.
采用连续溴脱氧尿苷（BrdU）和[3H]胸腺嘧啶核苷标记方案，研究了正常大鼠结肠隐窝中干细胞的位置和结肠上皮细胞的迁移方向。结果表明，在远端结肠中，干细胞位于隐窝底部，细胞向上朝着管腔表面迁移。然而，在近端结肠中，干细胞位于隐窝中部，结肠上皮细胞向两个方向迁移，向上朝着管腔表面，向下朝着隐窝底部。
