Chiodera P, Coiro V
Department of Internal Medicine, School of Medicine, University of Parma, Italy.
Brain Res. 1992 Jan 8;569(1):173-6. doi: 10.1016/0006-8993(92)90387-o.
In order to establish possible stimulatory effects of increasing plasma concentrations of substance P (SP) on the arginine vasopressin (AVP) and/or oxytocin (OT) secretion, successively increasing doses of SP(0.5, 1 and 1.5 pmol/kg-1/min-1; each dose for 20 min) were infused in 7 normal men. Plasma AVP and OT levels were measured before infusion and every 20 min, just before increasing the infusion dose of SP. During tests, SP infusion did not produce untoward side effects or changes in blood osmolality and/or pressure. Plasma OT levels did not change during SP infusion. Plasma AVP concentrations were not modified by the infusion of the lowest dose of SP, whereas they were significantly increased in a dose response fashion when higher amounts of SP were given. These findings demonstrate for the first time in humans that the systemic administration of SP exerts stimulatory effects on AVP, but not on OT secretion.
为了确定血浆中P物质（SP）浓度升高对精氨酸加压素（AVP）和/或催产素（OT）分泌可能产生的刺激作用，对7名正常男性连续输注递增剂量的SP（0.5、1和1.5 pmol/kg-1/min-1；每个剂量持续20分钟）。在输注前以及每次增加SP输注剂量前20分钟测量血浆AVP和OT水平。测试期间，SP输注未产生不良反应，也未引起血液渗透压和/或血压变化。SP输注期间血浆OT水平未改变。输注最低剂量的SP时，血浆AVP浓度未改变，而给予更高剂量的SP时，血浆AVP浓度呈剂量反应方式显著升高。这些发现首次在人体中证明，全身性给予SP对AVP分泌有刺激作用，但对OT分泌无刺激作用。
