Darwin B S, Herzberg A J, Murray J C, Olsen E A
Department of Medicine, Duke University Medical Center, Durham, NC 27710.
J Am Acad Dermatol. 1992 May;26(5 Pt 2):828-32. doi: 10.1016/0190-9622(92)70115-v.
Xanthomas can occur in association with underlying lymphoproliferative disease, or they can result from lipid deposition in damaged or altered skin. We report a case of generalized papular xanthomas that developed in a patient with Sézary syndrome. The xanthomas were composed of foamy histiocytes that were shown by immunoperoxidase staining to be of the monocyte/macrophage lineage. Electron microscopic studies revealed lipid vacuoles, lysosomes, and myelin figures but no Birbeck granules, features that are consistent with a non-X histiocytosis. Generalized papular xanthomatosis has not been previously described in a patient with cutaneous T-cell lymphoma.
黄瘤可与潜在的淋巴增殖性疾病相关联出现，也可由脂质沉积于受损或改变的皮肤所致。我们报告一例在蕈样肉芽肿综合征患者中发生的泛发性丘疹性黄瘤病例。这些黄瘤由泡沫状组织细胞构成，免疫过氧化物酶染色显示其为单核细胞/巨噬细胞谱系。电子显微镜研究揭示有脂质空泡、溶酶体和髓鞘样结构，但无伯贝克颗粒，这些特征与非X组织细胞增生症相符。泛发性丘疹性黄瘤病此前尚未在皮肤T细胞淋巴瘤患者中被描述过。
