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1
The inhibition of mast cell damage and histamine release in anaphylaxis by pyridine and diphosphopyridine nucleotidase inhibitors. Comparison with compound 48/80.吡啶和二磷酸吡啶核苷酸酶抑制剂对过敏反应中肥大细胞损伤和组胺释放的抑制作用。与化合物48/80的比较。
Br J Pharmacol Chemother. 1960 Sep;15(3):405-9. doi: 10.1111/j.1476-5381.1960.tb01263.x.
2
The anti-anaphylactic and histamine-releasing properties of the antihistamines. Their effect on the mast cells.抗组胺药的抗过敏和组胺释放特性。它们对肥大细胞的作用。
Br J Pharmacol Chemother. 1960 Sep;15(3):396-404. doi: 10.1111/j.1476-5381.1960.tb01262.x.
3
Inhibition of mast cell disruption and histamine release in rat anaphylaxis in vitro. Comparison with compound 48/80.体外抑制大鼠过敏反应中肥大细胞破坏和组胺释放。与化合物48/80的比较。
Br J Pharmacol Chemother. 1960 Mar;15(1):82-7. doi: 10.1111/j.1476-5381.1960.tb01213.x.
4
Action of anaphylactic shock and anaphylatoxin on mast cells and histamine in rats.过敏性休克和过敏毒素对大鼠肥大细胞及组胺的作用
Br J Pharmacol Chemother. 1957 Dec;12(4):453-6. doi: 10.1111/j.1476-5381.1957.tb00164.x.
5
Effects of anaphylactic shock and compound 48/80 on the mast cells of the guinea pig lung.过敏性休克和化合物48/80对豚鼠肺肥大细胞的影响。
Nature. 1956 Mar 3;177(4505):427-9. doi: 10.1038/177427a0.
6
Inhibitory effects of carbohydrates on histamine release and mast cell disruption by dextran.碳水化合物对右旋糖酐诱导的组胺释放和肥大细胞破坏的抑制作用。
Br J Pharmacol Chemother. 1962 Dec;19(3):405-13. doi: 10.1111/j.1476-5381.1962.tb01445.x.
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The inhibitory effect of nicotinamide on asthma-like symptoms and eosinophilia in guinea pigs, anaphylactic mast cell degranulation in mice, and histamine release from rat isolated peritoneal mast cells by compound 48-80.烟酰胺对豚鼠哮喘样症状和嗜酸性粒细胞增多、小鼠过敏性肥大细胞脱颗粒以及化合物48 - 80诱导的大鼠离体腹膜肥大细胞组胺释放的抑制作用。
Int Arch Allergy Appl Immunol. 1974;47(5):737-48. doi: 10.1159/000231265.
8
Evidence for energy-requiring processes in histamine release and mast cell degranulation in rat tissues induced by compound 48/80.化合物48/80诱导大鼠组织中组胺释放和肥大细胞脱颗粒过程中能量需求过程的证据。
Acta Physiol Scand. 1961 Nov-Dec;53:315-29. doi: 10.1111/j.1748-1716.1961.tb02290.x.
9
OXYGEN CONSUMPTION OF ISOLATED MAST CELLS IN THE ANAPHYLACTIC REACTION.过敏反应中分离肥大细胞的耗氧量
Nature. 1964 Apr 4;202:93-4. doi: 10.1038/202093a0.
10
Anti-allergic activity of German chamomile (Matricaria recutita L.) in mast cell mediated allergy model.德国甘菊（Matricaria recutita L.）在肥大细胞介导的过敏模型中的抗过敏活性。
J Ethnopharmacol. 2011 Sep 1;137(1):336-40. doi: 10.1016/j.jep.2011.05.029. Epub 2011 May 31.

引用本文的文献

1
Mast cells and anaphylaxis.肥大细胞与过敏反应。
Experientia. 1962 Jun 15;18:286-8. doi: 10.1007/BF02148240.
2
EFFECTS OF ANTI-RHEUMATIC COMPOUNDS AND PYRIDINE DERIVATIVES ON THE CUTANEOUS RESPONSE TO THURFYL NICOTINATE IN THE GUINEA-PIG.抗风湿化合物及吡啶衍生物对豚鼠皮肤对烟酰替芬反应的影响
Br J Pharmacol Chemother. 1963 Aug;21(1):104-12. doi: 10.1111/j.1476-5381.1963.tb01506.x.
3
Inhibitory effects of carbohydrates on histamine release and mast cell disruption by dextran.碳水化合物对右旋糖酐诱导的组胺释放和肥大细胞破坏的抑制作用。
Br J Pharmacol Chemother. 1962 Dec;19(3):405-13. doi: 10.1111/j.1476-5381.1962.tb01445.x.
4
[Mast cells and mast cell degranulation].[肥大细胞与肥大细胞脱颗粒]
Klin Wochenschr. 1966 Oct 15;44(20):1177-82. doi: 10.1007/BF01742094.
5
Tribenoside as an inhibitor of chemically induced histamine release.曲克芦丁作为化学诱导组胺释放的抑制剂。
Experientia. 1974 Apr 15;30(4):399-401. doi: 10.1007/BF01921686.
6
The influence of nicotinamide on the course of experimental bronchial asthma in guinea pig.烟酰胺对豚鼠实验性支气管哮喘病程的影响。
Agents Actions. 1973 Oct;3(3):176. doi: 10.1007/BF01965732.
7
Histamine and its metabolism in mammals. Part II: Catabolism of histamine and histamine liberation.组胺及其在哺乳动物体内的代谢。第二部分：组胺的分解代谢与组胺释放
Agents Actions. 1975 Aug;5(3):183-225. doi: 10.1007/BF02026434.

本文引用的文献

1
Effect of antigen and octylamine on mast cells and histamine content of sensitized guinea-pig tissues.抗原和辛胺对致敏豚鼠组织中肥大细胞及组胺含量的影响。
J Physiol. 1959 Oct;147(3):425-36. doi: 10.1113/jphysiol.1959.sp006253.
2
The mechanism of anaphylaxis: specificity of antigen-induced mast cell damage in anaphylaxis in the guinea pig.过敏反应的机制：豚鼠过敏反应中抗原诱导肥大细胞损伤的特异性。
Immunology. 1959 Jan;2(1):31-43.
3
Formation of histamine-containing dinucleotides by enzymatic interaction of histamine and coenzyme I.通过组胺与辅酶I的酶促相互作用形成含组胺的二核苷酸。
Nature. 1958 Jan 24;181(4604):271-2. doi: 10.1038/181271a0.
4
Inhibition of the anaphylactic reaction.过敏反应的抑制
J Physiol. 1957 Feb 15;135(2):301-19. doi: 10.1113/jphysiol.1957.sp005712.
5
Effects of anaphylactic shock and compound 48/80 on the mast cells of the guinea pig lung.过敏性休克和化合物48/80对豚鼠肺肥大细胞的影响。
Nature. 1956 Mar 3;177(4505):427-9. doi: 10.1038/177427a0.
6
Inhibition of spleen diphosphopyridine nucleotidase by nicotinamide, an exchange reaction.烟酰胺对脾二磷酸吡啶核苷酸酶的抑制作用，一种交换反应。
J Biol Chem. 1953 Jan;200(1):197-212.

吡啶和二磷酸吡啶核苷酸酶抑制剂对过敏反应中肥大细胞损伤和组胺释放的抑制作用。与化合物48/80的比较。

The inhibition of mast cell damage and histamine release in anaphylaxis by pyridine and diphosphopyridine nucleotidase inhibitors. Comparison with compound 48/80.

作者信息

MOTA I, da SILVA W, FERNANDES J F

出版信息

Br J Pharmacol Chemother. 1960 Sep;15(3):405-9. doi: 10.1111/j.1476-5381.1960.tb01263.x.

DOI:10.1111/j.1476-5381.1960.tb01263.x
PMID:13773170
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1481840/
Abstract

In rats and guinea-pigs both mast cell damage and histamine release in anaphylaxis were inhibited by pyridine, nicotinamide, diethylnicotinamide, nicotinic acid, isonicotinic acid and isonicotinic acid hydrazide, which are known to be inhibitors of diphosphopyridine nucleotidases. On the other hand these compounds potentiated histamine release and mast cell damage by compound 48/80 in guinea-pigs although inhibiting the same phenomena in rats. The relationship of these findings with the mechanism of histamine liberation in anaphylaxis is discussed.

摘要

已知吡啶、烟酰胺、二乙烟酰胺、烟酸、异烟酸和异烟肼是二磷酸吡啶核苷酸酶的抑制剂，它们可抑制大鼠和豚鼠过敏反应中的肥大细胞损伤和组胺释放。另一方面，这些化合物增强了豚鼠因化合物48/80引起的组胺释放和肥大细胞损伤，尽管在大鼠中抑制了相同的现象。本文讨论了这些发现与过敏反应中组胺释放机制的关系。