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10-甲氧基哈尔满,一种影响条件性行为的强效血清素拮抗剂。

10-Methoxyharmalan, a potent serotonin antagonist which affects conditioned behavior.

作者信息

MCISAAC W M, KHAIRALLAH P A, PAGE I H

出版信息

Science. 1961 Sep 8;134(3480):674-5. doi: 10.1126/science.134.3480.674.

DOI:10.1126/science.134.3480.674
PMID:13774014
Abstract

10-Methoxyharmalan, an alkaloid obtained by the cyclodehydration of melatonin, itself a derivative of serotonin, is a more potent serotonin antagonist than harmaline and is only slightly less active than lysergic acid diethylamide. It has a similar, yet slightly greater, effect on behavior as that of harmaline and is the most potent serotonin derivative, so far tested, that affects the avoidance-escape behavioral reflex

摘要

10-甲氧基哈马灵是一种通过褪黑素环脱水得到的生物碱,而褪黑素本身是血清素的衍生物。它是一种比哈马灵更强效的血清素拮抗剂,其活性仅略低于麦角酸二乙酰胺。它对行为的影响与哈马灵相似,但略强,是迄今为止测试过的影响逃避行为反射的最有效的血清素衍生物。

相似文献

1
10-Methoxyharmalan, a potent serotonin antagonist which affects conditioned behavior.10-甲氧基哈尔满,一种影响条件性行为的强效血清素拮抗剂。
Science. 1961 Sep 8;134(3480):674-5. doi: 10.1126/science.134.3480.674.
2
Brom-lysergic acid diethylamide: a highly potent serotonin antagonist.溴麦角酰二乙胺:一种高效的血清素拮抗剂。
J Pharmacol Exp Ther. 1956 May;117(1):10-5.
3
Identification of antiepileptic properties of a lysergic-acid-derivative-UML 491-serotonin antagonist; preliminary report.
Med Exp Int J Exp Med. 1960;2:36-9. doi: 10.1159/000134839.
4
[Preparation of new semi-synthetic lysergic acid derivatives: correlation of molecular structure and antiserotonin acitivity. II].[新型半合成麦角酸衍生物的制备:分子结构与抗血清素活性的相关性。II]
Acta Pharm Hung. 1973 Sep;43(5):207-17.
5
Lysergic acid diethylamide antagonism of certain drugs.麦角酸二乙酰胺对某些药物的拮抗作用。
Ann N Y Acad Sci. 1957 Mar 14;66(3):677-85. doi: 10.1111/j.1749-6632.1957.tb40757.x.
6
[TOLERANCE PHENOMENA NOTED DURING ALTERATION OF CONDITIONED REACTIONS BY NORADRENALIN, SEROTONIN AND LYSERGIC ACID DIETHYLAMIDE].[去甲肾上腺素、血清素和麦角酸二乙胺改变条件反应过程中观察到的耐受现象]
Acta Biol Med Ger. 1963;11:849-58.
7
Displacement of specific serotonin and lysergic acid diethylamide binding by Ergalgin, a new antiserotonin drug.新型抗血清素药物厄尔加金对特定血清素和麦角酸二乙酰胺结合的置换作用
Acta Biol Med Ger. 1980;39(8-9):897-901.
8
[Specific inhibition of serotonin effects by lysergic acid diethylamide and similar compounds].[麦角酸二乙酰胺及类似化合物对血清素效应的特异性抑制作用]
Naunyn Schmiedebergs Arch Exp Pathol Pharmakol. 1956;228(1-2):146-8.
9
[Considerations on the mechanism of action of lysergic acid diethylamine].关于麦角酸二乙胺作用机制的思考
Boll Soc Ital Biol Sper. 1956 Jan-Feb;32(1-2):25-6.
10
The antagonism between 5-hydroxytryptamine and certain derivatives of lysergic acid.5-羟色胺与麦角酸某些衍生物之间的拮抗作用。
Br J Pharmacol Chemother. 1956 Sep;11(3):313-7. doi: 10.1111/j.1476-5381.1956.tb01072.x.

引用本文的文献

1
Electroencephalographic and behavioral effects of harmaline in intact cats and in cats with chronic mesencephalic transection.
Psychopharmacologia. 1970;17(4):302-13. doi: 10.1007/BF00404235.
2
Growth-inhibiting effect of crude pineal extracts on human melanoma cells in vitro is different from that of known synthetic pineal substances.松果体粗提物对人黑色素瘤细胞的体外生长抑制作用不同于已知的合成松果体物质。
J Neural Transm. 1987;69(3-4):299-311. doi: 10.1007/BF01244350.