Tu Z
Institute of Hepatobiliary Surgery, Changhai Hospital, Shanghai.
Zhonghua Yi Xue Za Zhi. 1992 Mar;72(3):138-40, 189.
Levels of alpha-fetoprotein reactive to lentil lectin (AFP-R-L) were monitored in 27 patients with 20-400 micrograms AFP/L and negative imaging. These cases finally were proven to be affected by hepatocellular carcinoma. AFP-R-L above 25% was used to define the positive result for hepatocellular carcinoma. The positivity of AFP-R-L was 63%. At the same time, AFP-R-L was detected in 71 cases of chronic liver diseases. All but one had negative AFP-R-L values. The results suggested that AFP-R-L could make a dissection 3-28 months earlier than positive imaging. An accuracy of predicting hepatoma with positive AFP-R-L was 94%. So the diagnosis of hepatoma with negative imaging could be early made by measurement of AFP-R-L.
对27例甲胎蛋白（AFP）水平为20 - 400微克/升且影像学检查呈阴性的患者监测了对扁豆凝集素反应性的甲胎蛋白（AFP-R-L）水平。这些病例最终被证实患有肝细胞癌。AFP-R-L高于25%被用于定义肝细胞癌的阳性结果。AFP-R-L的阳性率为63%。同时，在71例慢性肝病患者中检测了AFP-R-L。除1例之外其余均为AFP-R-L值阴性。结果表明，AFP-R-L比阳性影像学检查能够提前3 - 28个月做出诊断。AFP-R-L阳性预测肝癌的准确率为94%。因此，通过检测AFP-R-L可以早期诊断影像学检查呈阴性的肝癌。
