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[稳定的α2-巨球蛋白浓缩物在实验性烧伤中的应用效果]

[Efficacy of the use of a stabilized alpha2-macroglobulin concentrate in experimental burns].

作者信息

Perekhrestenko P M, Lositskaia V M, Lobunets K A, Voloshina M S, Sizov V M, Iakovenko S B, Mashchenko V A, Evtukh V P

出版信息

Klin Khir (1962). 1992(3):30-2.

PMID:1377762
Abstract

The effectiveness of the use of a stabilized composition of alpha 2-macroglobulin concentrate obtained from fraction III of plasma proteins according to Cohn in burn disease in the experiment on guinea pigs was studied. Under the influence of intraabdominal administration for 4 days of alpha 2-macroglobulin concentrate with a stabilizer, healing of the burn wounds, normalization of a state of the animals occurred 2 times more rapidly than in control ones, activity of acid proteinases restored by day 5 (in control--by day 14) due to increase in activity of proteolytic enzyme inhibitors.

摘要

研究了在豚鼠实验中,使用根据科恩方法从血浆蛋白III组分获得的α2-巨球蛋白浓缩物的稳定组合物治疗烧伤疾病的有效性。在腹腔内给予含稳定剂的α2-巨球蛋白浓缩物4天的影响下,烧伤创面愈合,动物状态恢复正常的速度比对照组快2倍,酸性蛋白酶的活性在第5天恢复(对照组在第14天恢复),这是由于蛋白水解酶抑制剂活性增加所致。

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