Urakami K, Takahashi K, Saito H, Okada A, Nakamura S, Tanaka S, Kitaguchi N, Tokushima Y, Yamamoto S
Division of Neurology, Faculty of Medicine, Tottori University, Japan.
Acta Neurol Scand. 1992 May;85(5):343-6. doi: 10.1111/j.1600-0404.1992.tb04057.x.
We used the ELISA to measure the concentration of amyloid protein precursor with Kunitz type trypsin inhibitor domains (APPI) in CSF of dementia of the Alzheimer type (DAT) and examined the correlation of APPI with acetylcholinesterase (AChE) and somatostatin (SRIF). We found the APPI concentration in CSF of DAT to be significantly elevated compared with that of multi-infarct dementia and controls. We could significantly correlate APPI with AChE, but not correlate APPI with SRIF. The present results suggest that measurement of CSF APPI levels may be useful for diagnosis of DAT and the change of APPI may closely be associated with abnormality of acetylcholine system in DAT that has been reported.
我们使用酶联免疫吸附测定法（ELISA）来测量阿尔茨海默型痴呆（DAT）患者脑脊液中具有库尼茨型胰蛋白酶抑制剂结构域的淀粉样蛋白前体（APPI）的浓度，并检测APPI与乙酰胆碱酯酶（AChE）和生长抑素（SRIF）之间的相关性。我们发现，与多发梗死性痴呆患者及对照组相比，DAT患者脑脊液中APPI的浓度显著升高。我们能够显著地将APPI与AChE相关联，但无法将APPI与SRIF相关联。目前的结果表明，测量脑脊液中APPI的水平可能有助于DAT的诊断，并且APPI的变化可能与已报道的DAT中乙酰胆碱系统的异常密切相关。
