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人类心脏移植受者的淋巴细胞组织培养研究。III. 基于免疫学研究对移植结果的预测。

Lymphocyte tissue culture studies on human heart transplant recipients. III. Prediction of outcome of transplantation based on immunologic studies.

作者信息

Coulson A S, Zeitman V H, Struthers C, Dong E, Stinson E B, Griepp R B, Cohn R B, Shumway N E

出版信息

Clin Exp Immunol. 1976 Dec;26(3):623-31.

PMID:137791
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1540977/
Abstract

Using in vitro lymphocyte tissue culture screening tests human heart transplant recipients during the academic year 1973/1974 were evaluated and an attempt made to predict their post-operative rejection course. The tests involved screening for serum depressive factors and screening for the recipient's lymphocyte reactivity. A scoring system was devised whereby the laboratory results could be converted to a predicted rejection score. Of the nine patients studied, eight are still doing well. Three recipient's who had a high postoperative rejection score as determined by an independent clinical team, were correctly identified pre-operatively and one of them had to be retransplanted. These screening tests may be helpful in the future in the selection of recipients.

摘要

在1973/1974学年,利用体外淋巴细胞组织培养筛选试验对心脏移植受者进行了评估,并试图预测他们术后的排斥反应过程。这些试验包括血清抑制因子筛查和受者淋巴细胞反应性筛查。设计了一个评分系统,据此可将实验室结果转化为预测的排斥评分。在研究的9名患者中,有8名情况仍然良好。一个独立的临床团队确定有3名受者术后排斥评分较高,术前被正确识别,其中1人不得不再次接受移植。这些筛查试验未来可能有助于受者的选择。

相似文献

1
Lymphocyte tissue culture studies on human heart transplant recipients. III. Prediction of outcome of transplantation based on immunologic studies.人类心脏移植受者的淋巴细胞组织培养研究。III. 基于免疫学研究对移植结果的预测。
Clin Exp Immunol. 1976 Dec;26(3):623-31.
2
Prediction of outcome of human heart transplantation based on lymphocyte tissue culture studies.基于淋巴细胞组织培养研究对人类心脏移植结果的预测
Surg Forum. 1975;26:333-4.
3
Clinical relevance of in vitro propagation of activated lymphocytes from endomyocardial biopsy samples of pediatric heart transplant recipients.小儿心脏移植受者心内膜心肌活检样本中活化淋巴细胞体外增殖的临床相关性
Pediatr Transplant. 1998 Aug;2(3):200-5.
4
Relationship of donor-specific mixed lymphocyte culture reactivity to graft function in recipients of cadaveric renal allografts.尸体肾移植受者中供者特异性混合淋巴细胞培养反应性与移植肾功能的关系。
Clin Exp Immunol. 1979 Jun;36(3):521-7.
5
Lymphocyte tissue culture studies on human heart transplant recipients. II. Screening the lymphocyte reactivity of the recipients in vitro.人类心脏移植受者的淋巴细胞组织培养研究。II. 体外筛选受者的淋巴细胞反应性。
Transplantation. 1974 Nov;18(5):409-16. doi: 10.1097/00007890-197411000-00004.
6
Inhibition of mixed leukocyte culture reactivity by sera from hemodialysis patients and transplant recipients as an indicator of isoimmunization.血液透析患者和移植受者血清对混合淋巴细胞培养反应性的抑制作用作为同种免疫的指标。
Lab Invest. 1974 Jul;31(1):1-5.
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Pre- and posttransplantation immunologic monitoring assays for human cardiac transplantation.人类心脏移植的移植前和移植后免疫监测检测方法
Transplant Proc. 1979 Jun;11(2):1239-40.
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The inhibitory effects of pravastatin on natural killer cell activity in vivo and on cytotoxic T lymphocyte activity in vitro.普伐他汀对体内自然杀伤细胞活性及体外细胞毒性T淋巴细胞活性的抑制作用。
J Heart Lung Transplant. 1998 Apr;17(4):335-40.
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Improved renal allograft survival using the mixed lymphocyte culture for selection of nonidentical living related donors.使用混合淋巴细胞培养法选择非同基因活体亲属供体以提高肾移植存活率。
Trans Am Soc Artif Intern Organs. 1975;21:90-5.
10
[The significance of mixed lymphocyte culture and mitogen-stimulated culture for kidney transplantation (author's transl)].混合淋巴细胞培养及促细胞分裂剂刺激培养在肾移植中的意义(作者译)
Wien Klin Wochenschr. 1981 Jul 10;93(14):457-60.

本文引用的文献

1
Quantitation of the response of lymphocytes in culture to specific and non-specific stimulation.培养的淋巴细胞对特异性和非特异性刺激反应的定量分析。
Int Arch Allergy Appl Immunol. 1967;32(2):117-30. doi: 10.1159/000229922.
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Clarification on the effects of the heat of solution of dimethyl sulfoxide and the latent heat of fusion of ice on lymphocytes using an in vitro test for viability.
Cryobiology. 1966 Mar-Apr;2(5):263-7. doi: 10.1016/s0011-2240(66)80132-3.
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Lymphocyte tissue culture in transplant surgery.移植手术中的淋巴细胞组织培养。
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4
Acute rejection of the allogrfted human heart.移植入人体心脏的急性排斥反应。
Ann Thorac Surg. 1971 Aug;12(2):113-26. doi: 10.1016/s0003-4975(10)65102-8.
5
Correlation between mixed lymphocyte culture performed before renal transplantation and kidney function.肾移植前进行的混合淋巴细胞培养与肾功能之间的相关性。
Clin Exp Immunol. 1970 Jun;6(6):821-7.
6
Cardiac transplantation in man. 3. Surgical aspects.人类心脏移植。3. 手术方面。
Am J Surg. 1969 Aug;118(2):182-7. doi: 10.1016/0002-9610(69)90118-4.
7
In vitro stimulation of murine spleen cells using a microculture system and a multiple automated sample harvester.使用微量培养系统和多重自动样本采集器对小鼠脾细胞进行体外刺激。
J Immunol Methods. 1973 Apr;2(3):279-91. doi: 10.1016/0022-1759(73)90054-9.
8
Serum blocking factors in human recipients of renal allografts.肾移植人类受者中的血清封闭因子。
Transplantation. 1974 Apr;17(4):361-70. doi: 10.1097/00007890-197404000-00005.
9
Percutaneous transvenous endomyocardial biopsy.经皮经静脉心内膜心肌活检
JAMA. 1973 Jul 16;225(3):288-91.
10
Reactivity of lymphocytes in mixed culture in response to human renal transplantation.
Surgery. 1972 Aug;72(2):220-8.