Jonveaux P, Berger R
Unité INSERM U 301, Institut de Génétique Moléculaire, Paris, France.
Genes Chromosomes Cancer. 1992 Jun;4(4):321-5. doi: 10.1002/gcc.2870040408.
Four patients with plasma cell leukemia (PCL) and two with multiple myeloma (MM) in transformation had complex numerical and structural chromosome abnormalities. From data published in the literature, the cytogenetic patterns of 46 cases of PCL or MM in the leukemic phase are compared with chromosomal abnormalities found in MM. Although the spectrum of chromosomal abnormalities is comparable in both diseases, the incidence of chromosome abnormalities is higher in PCL than in MM. Hypodiploidy with monosomies for chromosomes 13, 16, 17, and 18 is also more frequent in PCL than in MM. A mutation within the TP53 gene was detected in one of the three patients studied molecularly.
4例浆细胞白血病（PCL）患者及2例处于转化期的多发性骨髓瘤（MM）患者存在复杂的染色体数目和结构异常。根据文献公布的数据，将46例处于白血病期的PCL或MM患者的细胞遗传学模式与MM中发现的染色体异常进行了比较。尽管两种疾病的染色体异常谱具有可比性，但PCL中染色体异常的发生率高于MM。13、16、17和18号染色体单体的亚二倍体在PCL中也比MM中更常见。在所研究的3例患者中的1例检测到TP53基因内的突变。
