神经递质与飞蝗直肠细胞中液体重吸收的刺激作用

Neurotransmitters and stimulation of fluid reabsorption in migratory locust rectal cells.

作者信息

Fournier B, Viratelle O, Hamoudi N, Proux J

机构信息

Laboratoire de Neuroendocrinologie, URA CNRS 1138, Université de Bordeaux I, Talence, France.

出版信息

Gen Comp Endocrinol. 1992 Jul;87(1):95-104. doi: 10.1016/0016-6480(92)90154-c.

DOI:10.1016/0016-6480(92)90154-c

PMID:1378034

Abstract

Several biogenic amines enhance fluid reabsorption and the accumulation of cyclic adenosine-monophosphate (cAMP) in the rectum of the migratory locust but only 5-hydroxytryptamine (5-HT) acts in a dose-dependent manner at low concentrations (between 10(-8) and 5.10(-7) M). Cyclic AMP is a second messenger of 5-HT, and its actions on fluid reabsorption are calcium-dependent. Polymyxin B (a protein kinase C inhibitor) mimics the actions of 5-HT on fluid reabsorption and on calcium-dependent cAMP accumulation. This suggests the presence of other sources of calcium and a possible relationship between several transduction systems within different rectal cells. The second messenger system mediating the 5-HT antidiuretic message differs from those involved in the transduction of the known locust antidiuretic hormones.

摘要

几种生物胺可增强飞蝗直肠中的液体重吸收和环磷酸腺苷（cAMP）的积累，但只有5-羟色胺（5-HT）在低浓度（10^(-8)至5×10^(-7) M之间）时呈剂量依赖性作用。环磷酸腺苷是5-HT的第二信使，其对液体重吸收的作用依赖于钙。多粘菌素B（一种蛋白激酶C抑制剂）模拟了5-HT对液体重吸收和钙依赖性cAMP积累的作用。这表明存在其他钙源，并且不同直肠细胞内的几种转导系统之间可能存在关联。介导5-HT抗利尿信息的第二信使系统与参与已知飞蝗抗利尿激素转导的系统不同。