Nahrendorf W, Rading A, Steinig G, van der Does R, Schlote A
Medizinische Akademie Magdeburg, Germany.
J Cardiovasc Pharmacol. 1992;19 Suppl 1:S114-6. doi: 10.1097/00005344-199219001-00022.
The beta-blocking and vasodilating agent carvedilol was compared with a combination of propranolol and isosorbide dinitrate (ISDN) in a double-blind, parallel-group study. After two baseline sitting bicycle exercise tests on placebo, 31 patients with chronic stable angina were asymmetrically randomized to treatment with carvedilol (25 mg b.i.d.) or propranolol-ISDN (80 mg/20 mg b.i.d.) for a period of 6 months. Further exercise tests were performed 2 h after the first dose as well as after 1, 3, and 6 months of treatment. Twenty-seven patients were considered evaluable for efficacy. Differences between the two groups were observed with emphasis on total exercise time and time to 1-mm ST-segment depression. In contrast to a greater peak effect of the first propranolol/ISDN dose, the chronic antianginal and anti-ischemic effects of carvedilol at trough were found to be more marked than those of the combination.
在一项双盲、平行组研究中，对β受体阻滞剂兼血管扩张剂卡维地洛与普萘洛尔和硝酸异山梨酯（ISDN）联合用药进行了比较。在接受两次安慰剂基础状态下的坐位自行车运动试验后，31例慢性稳定型心绞痛患者被非对称随机分为接受卡维地洛（25毫克，每日两次）或普萘洛尔 - ISDN（80毫克/20毫克，每日两次）治疗6个月。在首剂用药后2小时以及治疗1、3和6个月后进行了进一步的运动试验。27例患者被认为可进行疗效评估。观察了两组之间的差异，重点是总运动时间和出现1毫米ST段压低的时间。与首剂普萘洛尔/ISDN的更大峰值效应相反，发现卡维地洛谷值时的慢性抗心绞痛和抗缺血作用比联合用药更为显著。
