Cournot A, Lim C, Duchier J, Safar M
Department of Internal Medicine, Institut National de la Sante et de la Recherche Medicale (INSERM U 337), Broussais Hospital, Paris, France.
J Cardiovasc Pharmacol. 1992;19 Suppl 1:S35-9. doi: 10.1097/00005344-199219001-00008.
Forearm hemodynamics using pulsed Doppler flowmetry were studied in nine healthy volunteers and 12 patients with mild-to-moderate hypertension before and after acute oral administration of the beta-blocking and vasodilating agent carvedilol. Both the 25- and the 50-mg dose produced a significant blood pressure reduction by comparison with placebo in normotensive and hypertensive subjects. Only the 50-mg dose caused a decrease in forearm vascular resistance in hypertensive subjects. The decrease disappeared after wrist occlusion. Although brachial artery diameter did not change, a significant decrease in tangential tension was observed. This study provides evidence that carvedilol produced arteriolar dilation within the forearm of hypertensive subjects in association with a decrease in brachial artery tangential tension.
在9名健康志愿者和12名轻至中度高血压患者中，在急性口服β受体阻滞剂和血管扩张剂卡维地洛之前和之后，使用脉冲多普勒血流仪研究了前臂血流动力学。与安慰剂相比，25毫克和50毫克剂量在血压正常和高血压受试者中均使血压显著降低。仅50毫克剂量导致高血压受试者前臂血管阻力降低。手腕闭塞后，这种降低消失。尽管肱动脉直径没有变化，但观察到切向张力显著降低。这项研究提供了证据，表明卡维地洛在高血压受试者的前臂内产生小动脉扩张，并伴有肱动脉切向张力降低。
