Hegbrant J, Thysell H, Ekman R
Department of Nephrology, University Hospital, Lund, Sweden.
Scand J Urol Nephrol. 1992;26(2):169-76. doi: 10.1080/00365599.1992.11690449.
The fasting plasma levels of 10 vasoactive regulatory peptides were measured by radioimmunoassay in 23 stable patients with chronic renal failure receiving regular hemodialysis treatment (RDT) and compared with those of healthy controls. The plasma concentrations of arginine vasopressin, atrial natriuretic peptide, beta-endorphin, methionine-enkephalin, motilin, neuropeptide Y, substance P, and vasoactive intestinal peptide were increased. The plasma level of calcitonin gene-related peptide was not statistically different from that of the controls. The plasma concentration of gamma 2-melanocyte-stimulating hormone was lowered in the RDT-patients. The arterial blood pressure correlated with the plasma levels of motilin and neuropeptide Y. We conclude that patients with chronic renal failure receiving RDT have increased concentrations of 8 out of 10 measured vasoactive regulatory peptides. The elevated levels of vasoactive peptides may contribute to the adaptation of the cardiovascular system to impaired renal function.
采用放射免疫分析法测定了23例接受定期血液透析治疗（RDT）的稳定期慢性肾衰竭患者空腹血浆中10种血管活性调节肽的水平，并与健康对照者进行比较。精氨酸加压素、心钠素、β-内啡肽、甲硫氨酸脑啡肽、胃动素、神经肽Y、P物质和血管活性肠肽的血浆浓度升高。降钙素基因相关肽的血浆水平与对照组无统计学差异。RDT患者γ2-促黑素细胞激素的血浆浓度降低。动脉血压与胃动素和神经肽Y的血浆水平相关。我们得出结论，接受RDT的慢性肾衰竭患者所检测的10种血管活性调节肽中有8种浓度升高。血管活性肽水平升高可能有助于心血管系统适应受损的肾功能。
