Penner M J, Coles R R
Department of Psychology, University of Maryland, College Park 20742.
Br J Audiol. 1992 Apr;26(2):91-6. doi: 10.3109/03005369209077876.
This paper explores the effect of aspirin on the tinnitus of one patient for whom two contralateral spontaneous otoacoustic emissions (SOAEs) caused binaural tinnitus. The relation between the SOAEs and tinnitus was explored during a preliminary testing session, after which the SOAEs were measured for 7 days. During days 1, 2, 5, 6 and 7 of the trial, a placebo (two 50-mg tablets of ascorbic acid) was administered four times per day. During days 3 and 4, a drug (two 300-mg tablets of aspirin) was administered four times per day. During day 2, the right ear's SOAE was low level and labile, sometimes disappearing into the noise floor. The effect of aspirin on an emission which is not consistently observed, cannot be assessed so this report focuses primarily on the left ear. During days 1 and 2, the SOAE in the left ear was present and the tinnitus was audible. By day 3 (after 2.4 g of aspirin), the SOAE in the left ear had been abolished, and the tinnitus was not audible. On the fifth day (24 hours after the last aspirin), both the SOAE and the tinnitus in the left ear had returned. There were no reported side-effects of the aspirin. Thus, aspirin seemed to provide an acceptable palliative for this patient's SOAE-caused tinnitus.
本文探讨了阿司匹林对一名患者耳鸣的影响，该患者双侧自发性耳声发射（SOAE）引发了双耳耳鸣。在初步测试阶段探究了SOAE与耳鸣之间的关系，之后对SOAE进行了7天的测量。在试验的第1、2、5、6和7天，每天四次给予安慰剂（两片50毫克抗坏血酸片）。在第3和4天，每天四次给予药物（两片300毫克阿司匹林片）。在第2天，右耳的SOAE水平较低且不稳定，有时会消失在本底噪声中。由于无法评估阿司匹林对一种并非始终能观察到的耳声发射的影响，因此本报告主要关注左耳。在第1和2天，左耳存在SOAE且耳鸣可闻。到第3天（服用2.4克阿司匹林后），左耳的SOAE已消失，耳鸣也听不到了。在第5天（最后一次服用阿司匹林24小时后），左耳的SOAE和耳鸣又都出现了。未报告阿司匹林有副作用。因此，阿司匹林似乎为该患者由SOAE引起的耳鸣提供了一种可接受的缓解方法。
