JENKIN C, BENACERRAF B
J Exp Med. 1960 Aug 1;112(2):403-17. doi: 10.1084/jem.112.2.403.
Virulent strains of Salmonella opsonized with normal mouse plasma are never phagocytosed as well as avirulent strains. The virulent strains of Salmonella phagocytosed after opsonization with normal mouse plasma are able to multiply within normal mouse peritoneal macrophages, whereas under similar experimental conditions the avirulent strains are killed. When virulent strains of Salmonella are opsonized with specific antiserum or plasma from BCG-infected mice, they are treated by normal mouse macrophages as if they were avirulent. Virulent bacteria opsonized with BCG plasma are phagocytosed and killed better by peritoneal macrophages from BCG-infected mice, than peritoneal macrophages from normal mice.
用正常小鼠血浆调理的沙门氏菌强毒株,其被吞噬的情况永远不如无毒株。用正常小鼠血浆调理后被吞噬的沙门氏菌强毒株能够在正常小鼠腹膜巨噬细胞内繁殖,而在类似实验条件下无毒株则会被杀死。当沙门氏菌强毒株用特异性抗血清或卡介苗感染小鼠的血浆进行调理时,正常小鼠巨噬细胞对它们的处理方式就如同它们是无毒的一样。用卡介苗感染小鼠血浆调理的强毒细菌,被卡介苗感染小鼠的腹膜巨噬细胞吞噬和杀灭的效果,比正常小鼠的腹膜巨噬细胞更好。