使用全身性滴虫杀灭剂甲硝唑的实验室研究。
Laboratory studies with the systemic trichomonacide, metronidazole.
作者信息
JENNISON R F, STENTON P, WATT L
出版信息
J Clin Pathol. 1961 Jul;14(4):431-5. doi: 10.1136/jcp.14.4.431.
Abstract
Laboratory studies with the trichomonacidal agent, metronidazole, show that 66 strains of T. vaginalis were killed in three days by concentrations of 0.0625 mug./ml. to 1 mug./ml. Estimations of serum and urine levels in nine volunteers, the serum levels in 31 women, and the urine levels in 33 women show that metronidazole is rapidly absorbed and excreted in high concentration in the urine. Development of resistance to metronidazole by T. vaginalis has not been demonstrated either in vivo or in vitro. No toxic effect was demonstrated in the blood, liver, or kidney.
摘要
使用杀滴虫剂甲硝唑进行的实验室研究表明，浓度为0.0625微克/毫升至1微克/毫升的甲硝唑可在三天内杀死66株阴道毛滴虫。对9名志愿者的血清和尿液水平、31名女性的血清水平以及33名女性的尿液水平进行的测定表明，甲硝唑吸收迅速，且在尿液中高浓度排泄。阴道毛滴虫对甲硝唑产生耐药性的情况在体内或体外均未得到证实。在血液、肝脏或肾脏中未显示出毒性作用。
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