Yding Andersen C, Westergaard L G, Teisner B, Byskov A G, Ziebe S, Helledie L, Petersen K, Westergaard J G
Department of Obstetrics and Gynaecology, Rigshospitalet, Copenhagen, Denmark.
Hum Reprod. 1992 May;7(5):585-91. doi: 10.1093/oxfordjournals.humrep.a137700.
The profiles of plasma protein concentrations during the follicular phase in unstimulated women and in women undergoing ovarian stimulation for in-vitro fertilization--embryo transfer (IVF-ET) treatment are described. Plasma protein concentrations are correlated with those of total oestradiol (protein-bound and free) and total progesterone. In addition, 10 conception cycles and 18 non-conception cycles are compared in an attempt to identify predictors of successful treatment. Ovarian stimulation caused a significant increase in follicular phase in serum concentrations of sex hormone binding globulin (SHBG), cortisol binding protein (CBP) and insulin-like growth factor binding protein 1 (IGFBP1). In contrast no increase was observed in unstimulated cycles. Serum levels of endometrial protein PP14 decreased significantly during the follicular phase in both stimulated and unstimulated cycles. Levels of pregnancy zone protein (PZP) were more than doubled at the time of oocyte aspiration compared to the unstimulated cycles. Albumin concentrations were unchanged by the stimulation. Throughout the follicular phase, levels of SHBG were significantly higher, and total oestradiol significantly lower in women who became pregnant, than in those who did not. Therefore, a low concentration of free, biologically active oestradiol seemed to favour pregnancy, as the concentration of albumin is similar in the two groups. The endometrial protein PP14 was significantly lower during the follicular phase in conception than in non-conceptional cycles. On day 2 of the treatment cycle, the PP14 concentration showed a 75% correct prediction of conception and non-conception cycles. These results suggest that levels of PP14 may predict successful IVF cycles even before hormonal treatment is commenced.
本文描述了未接受刺激的女性以及接受体外受精 - 胚胎移植（IVF - ET）治疗的卵巢刺激女性在卵泡期的血浆蛋白浓度概况。血浆蛋白浓度与总雌二醇（结合型和游离型）及总孕酮的浓度相关。此外，比较了10个受孕周期和18个未受孕周期，试图确定成功治疗的预测指标。卵巢刺激导致卵泡期血清中性激素结合球蛋白（SHBG）、皮质醇结合蛋白（CBP）和胰岛素样生长因子结合蛋白1（IGFBP1）的浓度显著增加。相比之下，在未受刺激的周期中未观察到增加。在刺激和未刺激的周期中，卵泡期子宫内膜蛋白PP14的血清水平均显著下降。与未受刺激的周期相比，卵母细胞抽吸时妊娠区蛋白（PZP）的水平增加了一倍多。刺激对白蛋白浓度无影响。在整个卵泡期，怀孕女性的SHBG水平显著高于未怀孕女性，而总雌二醇水平显著低于未怀孕女性。因此，由于两组白蛋白浓度相似，低浓度的游离、具有生物活性的雌二醇似乎有利于怀孕。受孕周期卵泡期的子宫内膜蛋白PP14显著低于未受孕周期。在治疗周期的第2天，PP14浓度对受孕和未受孕周期的预测准确率为75%。这些结果表明，甚至在开始激素治疗之前，PP14水平可能就能预测IVF周期的成功与否。
