Kurishita A, Ono T, Okada S, Mori Y, Sawada S
Department of Radiation Research, Tohoku University School of Medicine, Sendai, Japan.
Mutat Res. 1992 Aug;268(2):323-8. doi: 10.1016/0027-5107(92)90238-w.
To assess the genetic effects of fission neutron, the induction of external malformations was studied in F1 fetuses after F0 male mice were irradiated. Male mice of the ICR:MCH strain were irradiated with 252Cf neutron at doses of 0.238, 0.475, 0.95 and 1.9 Gy. They were mated with non-irradiated female mice at 71-120 days after the irradiation. Pregnant females were autopsied on day 18 of gestation and their fetuses were examined for deaths and external abnormalities. No increases of pre- and post-implantation losses were noted at any dose. External abnormalities were observed at rates of 1.40% in the 0.238 Gy, 2.23% in the 0.475 Gy, 3.36% in the 0.95 Gy and 3.26% in the 1.9 Gy groups; the rate in the control group was 1.65%. The dose-response curve was linear up to 0.95 Gy, and then flattened out; the induction rate of external abnormalities was 2.7 x 10(-4)/gamete/cGy based on the linear regression. These results indicated that fission neutron effectively induces external abnormalities in F1 fetuses after spermatogonial irradiation.
为评估裂变中子的遗传效应，在对F0雄性小鼠进行辐照后，研究了F1胎儿外部畸形的诱导情况。将ICR:MCH品系的雄性小鼠用剂量为0.238、0.475、0.95和1.9 Gy的252Cf中子进行辐照。辐照后71 - 120天，将它们与未辐照的雌性小鼠交配。怀孕的雌性小鼠在妊娠第18天进行解剖，并检查其胎儿的死亡情况和外部异常。在任何剂量下均未观察到植入前和植入后损失的增加。在0.238 Gy组中，外部异常的发生率为1.40%；0.475 Gy组为2.23%；0.95 Gy组为3.36%；1.9 Gy组为3.26%；对照组的发生率为1.65%。剂量 - 反应曲线在0.95 Gy之前呈线性，之后趋于平缓；基于线性回归，外部异常的诱导率为2.7×10(-4)/配子/cGy。这些结果表明，裂变中子在精原细胞辐照后能有效诱导F1胎儿出现外部异常。
