Beetham R, Newman D
Department of Immunology, Westminster Hospital, London, UK.
Ann Clin Biochem. 1992 Jul;29 ( Pt 4):450-3. doi: 10.1177/000456329202900414.
In a preliminary investigation into the behaviour of low molecular weight proteins in the nephrotic syndrome, we have measured urinary concentrations of albumin, alpha-1-microglobulin (alpha 1-m) and retinol-binding protein (RBP) in six children for up to 11 days during the course of steroid therapy for nephrotic syndrome. The results in part support the concept of independent proximal tubular absorption of albumin and low molecular weight proteins, and indicate that in the nephrotic syndrome the excretion of RBP and alpha 1-m, two generally accepted markers of tubular proteinuria, is anomalous.
在一项关于肾病综合征中低分子量蛋白质行为的初步研究中，我们在6名儿童接受肾病综合征类固醇治疗的过程中，对其长达11天的尿白蛋白、α-1-微球蛋白（α1-m）和视黄醇结合蛋白（RBP）浓度进行了测量。结果部分支持白蛋白和低分子量蛋白质近端肾小管独立重吸收的概念，并表明在肾病综合征中，RBP和α1-m这两种普遍认可的肾小管性蛋白尿标志物的排泄是异常的。
