肾上腺素和去甲肾上腺素体外及体内O-甲基化的抑制剂。

Inhibitor of O-methylation of epinephrine and norepinephrine in vitro and in vivo.

作者信息

AXELROD J, LAROCHE M J

出版信息

Science. 1959 Sep 25;130(3378):800. doi: 10.1126/science.130.3378.800.

DOI:10.1126/science.130.3378.800

Abstract

Pyrogallol inhibits the Omethylation of epinephrine and norepinephrine by catechol-O-methyl transferase in vitro as well as the metabolism of these catecholamines, and the formation of their O-methylated metabolites, in the intact mouse. Since pyrogallol also prolongs the physiological effects of epinephrine, it is suggested that catechol-O-methyl transferase terminates the actions of the catecholamine hormones.

摘要

焦棓酚在体外能抑制儿茶酚-O-甲基转移酶对肾上腺素和去甲肾上腺素的甲基化作用，在完整小鼠体内也能抑制这些儿茶酚胺的代谢及其O-甲基化代谢产物的形成。由于焦棓酚还能延长肾上腺素的生理效应，因此有人提出儿茶酚-O-甲基转移酶可终止儿茶酚胺类激素的作用。