RYALL R W
Br J Pharmacol Chemother. 1961 Dec;17(3):339-57. doi: 10.1111/j.1476-5381.1961.tb01121.x.
Cocaine, imipramine and pipradol potentiated the contractions to adrenaline and noradrenaline, but not to tyramine, on the nictitating membrane of the spinal cat. Pheniprazine and dexamphetamine potentiated the responses to adrenaline, noradrenaline and tyramine, whereas nialamide only potentiated the response to tyramine. Potentiation of the response to stimulation of either the preganglionic or the postganglionic sympathetic nerve trunks was observed with imipramine, pipradol, pheniprazine and dexamphetamine. Only dexamphetamine and pheniprazine caused substantial contractions of the membrane when the preganglionic nerve was cut (acutely decentralized), or when the superior cervical ganglion was removed (acutely denervated). Cocaine produced contractions of the innervated but not of the acutely decentralized membrane. The significance of the peripheral effects of these antidepressant drugs in relation to their central actions is discussed.
可卡因、丙咪嗪和匹哌氮酯增强了脊髓猫瞬膜对肾上腺素和去甲肾上腺素的收缩反应，但对酪胺无此作用。苯乙肼和右旋苯丙胺增强了对肾上腺素、去甲肾上腺素和酪胺的反应，而尼亚酰胺仅增强了对酪胺的反应。丙咪嗪、匹哌氮酯、苯乙肼和右旋苯丙胺可增强对节前或节后交感神经干刺激的反应。当节前神经被切断（急性去中枢化）或颈上神经节被摘除（急性去神经支配）时，只有右旋苯丙胺和苯乙肼能引起瞬膜的显著收缩。可卡因可使有神经支配的瞬膜收缩，但不能使急性去中枢化的瞬膜收缩。本文讨论了这些抗抑郁药外周效应与其中枢作用的关系。
