呋喃西林对小鼠罗德西亚锥虫感染的影响。
The effect of nitrofurazone on Trypanosoma rhodesiense infections in mice.
作者信息
BAKER J R
出版信息
Br J Pharmacol Chemother. 1959 Sep;14(3):408-10. doi: 10.1111/j.1476-5381.1959.tb00267.x.
Abstract
Mice infected with a freshly isolated strain of Trypanosoma rhodesiense were not cured by ten daily intraperitoneal doses of 50, 100, 200, or 400 mg./kg. of nitrofurazone (5-nitrofurfuraldehyde semicarbazone). At the highest dosage used, the drug was lethal to some of the mice.
摘要
用刚分离出的罗德西亚锥虫株感染的小鼠，连续10天每天腹腔注射50、100、200或400毫克/千克的呋喃西林（5-硝基糠醛半卡巴腙）均不能治愈。在所用的最高剂量下，该药物对一些小鼠具有致死性。
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本文引用的文献
1
Antibiotic lactones and synthetic analogs. III. Efficacy in experimental trypanosomiasis.抗生素内酯及合成类似物。III. 实验性锥虫病中的疗效。
J Pharmacol Exp Ther. 1951 Jul;102(3):185-95.
2
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Am J Trop Med Hyg. 1957 Jul;6(4):658-64. doi: 10.4269/ajtmh.1957.6.658.
3
Chemotherapy of African sleeping sickness. I. Chemotherapy of experimental Trypanosoma gambiense infection in mice (Mus musculus) with nitrofurazone.非洲昏睡病的化学疗法。一、用呋喃西林对小鼠（小家鼠）实验性冈比亚锥虫感染进行化学疗法。
Am J Trop Med Hyg. 1955 Jul;4(4):705-11. doi: 10.4269/ajtmh.1955.4.705.
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