维生素B12国际参考制剂
International Reference Preparation for vitamin B12.
作者信息
BANGHAM D R, MUSSETT M V
出版信息
Bull World Health Organ. 1960;22(5):555-62.
Abstract
The International Reference Preparation for Vitamin B(12) was prepared in tablet form from a mixture of anhydrous cyanocobalamin and sodium chloride. In an international collaborative study, in which eleven laboratories participated, this preparation was examined qualitatively and quantitatively by spectrophotometric and microbiological methods. It was concluded that the International Reference Preparation is substantially pure and has a potency of 9.3 mug of cyanocobalamin per 20 mg of tablet.
摘要
维生素B12国际参考制剂由无水氰钴胺和氯化钠的混合物制成片剂形式。在一项有11个实验室参与的国际协作研究中，采用分光光度法和微生物学方法对该制剂进行了定性和定量检测。得出的结论是，该国际参考制剂基本纯净，每20毫克片剂中氰钴胺的效价为9.3微克。
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本文引用的文献
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Observations on the use of Lactobacillus leichmannii 4797 in the microbiological assay of vitamin B12.嗜酸乳杆菌4797在维生素B12微生物测定中的应用观察
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