Kraft D, Sirtl C, Laubenthal H, Scheiner O, Parth E, Dieterich H J, Szépfalusi Z, Trampisch H J, Gerlach E, Peter K
Institute of General and Experimental Pathology, University of Vienna, Austria.
Eur Surg Res. 1992;24(3):138-42. doi: 10.1159/000129200.
Using the highly sensitive ELISA technique for detecting anti-hydroxyethyl starch (HES) antibodies in man sera from 1,056 patients were analyzed. Patients of both sex, who had never had any prior contact with HES, were included in the study. In none of the cases could any titer of HES-reactive antibodies be detected. These data suggest that in man preformed HES-reactive antibodies do not exist or are extremely rare. In any case, unlike dextran-reactive antibodies, they should not have a high clinical importance. The mechanism behind the very rarely observed anaphylactoid reactions after HES application is still unknown.
采用高灵敏度酶联免疫吸附测定（ELISA）技术，对1056例患者的人血清中抗羟乙基淀粉（HES）抗体进行了分析。研究纳入了从未接触过HES的男性和女性患者。在所有病例中均未检测到任何滴度的HES反应性抗体。这些数据表明，人体内不存在预先形成的HES反应性抗体，或者极为罕见。无论如何，与右旋糖酐反应性抗体不同，它们应该没有很高的临床重要性。应用HES后极少观察到类过敏反应的背后机制仍不清楚。
