神经激肽激动剂对大鼠的A9和A10多巴胺能细胞有不同影响。
Neurokinin agonists differentially affect A9 and A10 dopamine cells in the rat.
作者信息
Overton P, Elliott P J, Hagan R M, Clark D
机构信息
Department of Psychology, University of Reading, Berkshire, U.K.
出版信息
Eur J Pharmacol. 1992 Mar 17;213(1):165-6. doi: 10.1016/0014-2999(92)90251-x.
The effect of selective neurokinin (NK) receptor agonists on the activity of A9 and A10 dopamine cells was assessed using extracellular recording. A higher proportion of A10 cells which were administered the NK1 receptor agonist GR73632 or the NK3 receptor agonist senktide showed an effect, whereas the NK2 receptor agonist GR64349 did not discriminate as clearly between the two cell groups. The most frequently encountered response in all cases was an increase in firing rate.
使用细胞外记录评估了选择性神经激肽（NK）受体激动剂对A9和A10多巴胺能细胞活性的影响。给予NK1受体激动剂GR73632或NK3受体激动剂senktide的A10细胞中有更高比例表现出效应，而NK2受体激动剂GR64349在区分这两组细胞时效果不那么明显。在所有情况下最常遇到的反应是放电率增加。
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