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[中耳聋与噪声损伤。运用表面标本技术的动物研究(作者译)]

[Middle ear deafness and noise trauma. Animal studies with the surface specimen technique (author's transl)].

作者信息

Leidenfrost U

出版信息

Laryngol Rhinol Otol (Stuttg). 1976 Dec;55(12):1005-10.

PMID:138031
Abstract

The pertinent clinical literature concerning the research project is reviewed. The middle ear of guinea pigs was first damaged on one side (inflicting a subtotal perforation of the tympanic membrane, dislocation of the incudo-stapedial joint followed by otitis media) and the animals were then exposed to a specified narrow-band noise. The induced inner ear changes were quantified by means of cochleographic studies using the surface specimen technique. In spite of the inner ear changes due to middle ear manipulation prior to the noise exposure, the cochleographic studies revealed an obvious protective effect of the induced middle ear changes upon the inner ear during noise exposure.

摘要

对与该研究项目相关的临床文献进行了综述。首先对豚鼠的一侧中耳造成损伤(造成鼓膜次全穿孔、砧镫关节脱位,随后引发中耳炎),然后将这些动物暴露于特定的窄带噪声中。通过使用表面标本技术的耳蜗电图研究对诱发的内耳变化进行量化。尽管在噪声暴露之前由于中耳操作导致了内耳变化,但耳蜗电图研究显示,在噪声暴露期间,诱发的中耳变化对内耳具有明显的保护作用。

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Laryngol Rhinol Otol (Stuttg). 1976 Dec;55(12):1005-10.
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Intra-tympanic delivery of short interfering RNA into the adult mouse cochlea.经鼓室内递送短发夹状 RNA 进入成年小鼠耳蜗。
Hear Res. 2013 Feb;296:36-41. doi: 10.1016/j.heares.2012.10.011. Epub 2012 Nov 23.