药物对大脑唤醒系统影响的比较研究。
A comparative study of the effects of drugs on the arousal system of the brain.
作者信息
BRADLEY P B, KEY B J
出版信息
Br J Pharmacol Chemother. 1959 Sep;14(3):340-9. doi: 10.1111/j.1476-5381.1959.tb00254.x.
Abstract
The effects of twelve drugs, eleven of which are reported to be tranquillizers, have been studied in relation to thresholds for arousal produced both by direct stimulation of the brain stem reticular formation and also by afferent nerve stimulation. The drugs can be grouped according to whether (a) like chlorpromazine they produce a slight rise in thresholds for brain stem stimulation and block sensory-induced arousal, (b) cause dissociation between behaviour and electrical activity of the brain, (c) have no effects on thresholds for brain stem stimulation and only slight effects on afferent nerve-induced arousal or (d) have no effect on arousal responses at all.
摘要
研究了12种药物的作用，其中11种据报道为镇静剂，研究内容涉及直接刺激脑干网状结构以及传入神经刺激所产生的唤醒阈值。这些药物可根据以下情况进行分类：(a) 像氯丙嗪一样，它们会使脑干刺激的阈值略有升高，并阻断感觉诱导的唤醒；(b) 导致大脑行为与电活动之间的分离；(c) 对脑干刺激的阈值没有影响，对传入神经诱导的唤醒只有轻微影响；或(d) 对唤醒反应完全没有影响。
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