Zatz M
Section on Biochemical Pharmacology, National Institute of Mental Health, Bethesda, MD 20892.
Brain Res. 1992 Jun 26;583(1-2):304-7. doi: 10.1016/s0006-8993(10)80039-3.
Previous experiments examined interactions among the effects of cyclic AMP and calcium-related agents on melatonin output by cultured chick pineal cells, and suggested that changes in calcium influx might act through cyclic AMP. Here, effects of calcium-related agents and manipulations on cyclic AMP (and cyclic GMP) levels are demonstrated directly. These effects support a role for cyclic AMP (but not cyclic GMP) in the effects of changes in calcium influx on melatonin production by these cells.
先前的实验研究了环磷酸腺苷（cAMP）和钙相关因子对培养的鸡松果体细胞褪黑素分泌的相互作用，并表明钙内流的变化可能通过环磷酸腺苷起作用。在此，直接证明了钙相关因子和操作对环磷酸腺苷（以及环磷酸鸟苷）水平的影响。这些影响支持环磷酸腺苷（而非环磷酸鸟苷）在钙内流变化对这些细胞褪黑素产生的影响中发挥作用。
