Rivera S, Sanfeliu C, García M, Comellas F, Rodríguez-Farré E
Department of Pharmacology and Toxicology, CSIC, Barcelona, Spain.
Neurotoxicology. 1992 Spring;13(1):235-9.
The neurotoxic agent lindane was tested for its ability to alter the rate of ultrasonic isolation calls of suckling rats. Doses that did not produce any sign of convulsant activity significantly increased the number of calls and the cumulative time of calling in male pups. At days 10-13 of age after a single dose of 20 mg/kg lindane, animals showed more than twice the control call values. After daily dosing with 10 mg/kg during the first week of age call increases also appeared. It is suggested that lindane has an anxiogenic effect mediated through its action on the benzodiazepine-GABAA receptor-chloride channel complex.
对神经毒性剂林丹改变乳鼠超声波隔离叫声速率的能力进行了测试。未产生任何惊厥活动迹象的剂量显著增加了雄性幼崽的叫声数量和累计鸣叫时间。在10 - 13日龄时单次给予20mg/kg林丹后，动物的叫声值是对照组的两倍多。在幼崽出生后第一周每天给予10mg/kg林丹后，也出现了叫声增加的情况。提示林丹通过作用于苯二氮䓬 - γ-氨基丁酸A受体 - 氯化物通道复合物产生致焦虑作用。
