Poje E J, Soori G S, Weisenburger D D
Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha 68198-3135.
Am J Clin Pathol. 1992 Aug;98(2):222-6. doi: 10.1093/ajcp/98.2.222.
The clinical and pathologic features of a case of acute systemic polyclonal B-immunoblastic proliferation characterized by pronounced peripheral blood and bone marrow plasmacytosis and infiltration of the hepatic portal areas by immunoblasts, plasma cells, and lymphocytes are reported. Clinical and laboratory findings during the acute phase and long-term follow-up support the diagnosis of a benign process, possibly related to Pseudomonas aeruginosa septicemia. The patient experienced a dramatic clinical recovery on administration of high-dose intravenous corticosteroids. Pathologists should be aware of this entity so as not to confuse it with non-Hodgkin's lymphoma or a form of plasma cell dyscrasia.
报告了一例急性系统性多克隆B免疫母细胞增殖病例的临床和病理特征，其特点为外周血和骨髓浆细胞增多，免疫母细胞、浆细胞和淋巴细胞浸润肝门区。急性期和长期随访期间的临床及实验室检查结果支持该良性过程的诊断，可能与铜绿假单胞菌败血症有关。患者在给予大剂量静脉注射糖皮质激素后临床症状显著改善。病理学家应了解这一实体，以免将其与非霍奇金淋巴瘤或浆细胞发育异常的一种形式相混淆。
