• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

Inhibition of aldosterone secretion and modification of electrolyte excretion in man by a chemical inhibitor of 11 beta-hydroxylation.

作者信息

COPPAGE W S, ISLAND D, SMITH M, LIDDLE G W

出版信息

J Clin Invest. 1959 Dec;38(12):2101-10. doi: 10.1172/JCI103988.

DOI:10.1172/JCI103988
PMID:13811859
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC293300/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8de3/293300/67ea95588710/jcinvest00336-0022-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8de3/293300/4dcd360ec980/jcinvest00336-0016-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8de3/293300/44db2491dedd/jcinvest00336-0019-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8de3/293300/89fe3210a897/jcinvest00336-0019-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8de3/293300/d19be30e71a5/jcinvest00336-0021-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8de3/293300/67ea95588710/jcinvest00336-0022-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8de3/293300/4dcd360ec980/jcinvest00336-0016-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8de3/293300/44db2491dedd/jcinvest00336-0019-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8de3/293300/89fe3210a897/jcinvest00336-0019-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8de3/293300/d19be30e71a5/jcinvest00336-0021-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8de3/293300/67ea95588710/jcinvest00336-0022-a.jpg

相似文献

1
Inhibition of aldosterone secretion and modification of electrolyte excretion in man by a chemical inhibitor of 11 beta-hydroxylation.11β-羟化作用的化学抑制剂对人体醛固酮分泌的抑制及电解质排泄的改变
J Clin Invest. 1959 Dec;38(12):2101-10. doi: 10.1172/JCI103988.
2
[EFFECT OF A SPIRONOLACTONE ALDOSTERONE INHIBITOR AND CHLOROTHIAZIDE ON WATER AND ELECTROLYTE EXCRETION IN LIVER DISEASES].[螺内酯(一种醛固酮抑制剂)和氯噻嗪对肝脏疾病患者水及电解质排泄的影响]
Srp Arh Celok Lek. 1964 Mar;92:301-8.
3
MODIFICATION OF ALDOSTERONE SECRETION AND ELECTROLYTE EXCRETION IN MAN BY A CHEMICAL INHIBITOR OF 18-OXIDATION.
J Clin Endocrinol Metab. 1964 Aug;24:740-6. doi: 10.1210/jcem-24-8-740.
4
Electrolyte retention produced by the antialdosterone SC 5233.抗醛固酮SC 5233引起的电解质潴留。
Nature. 1961 Sep 23;191:1308-9. doi: 10.1038/1911308a0.
5
[1st observations on the use of spirolactones (synthetic anti-aldosterone steroids) in pregnancy nephropathies].[关于螺内酯(合成抗醛固酮类固醇)在妊娠肾病中应用的首次观察]
Gynecol Obstet (Paris). 1961 Jul-Sep;60:443-50.
6
[The effects of new diuretics on the electrolyte balance, the aldosterone excretion and the behavior of the thromboelastogram in normal persons].[新型利尿剂对正常人电解质平衡、醛固酮排泄及血栓弹力图表现的影响]
Schweiz Med Wochenschr. 1961 Apr 29;91:515-9.
7
[Study of aldosterone antagonists, with special reference to the role of progesterone].[醛固酮拮抗剂的研究,特别提及孕酮的作用]
Rass Neurol Veg. 1961 Jul 31;15:420-32.
8
[Effects of the prolonged administration of aldosterone. Antagonistic action of glucocorticoids on the water-salt retention of aldosterone].[醛固酮长期给药的作用。糖皮质激素对醛固酮水盐潴留的拮抗作用]
Boll Soc Ital Biol Sper. 1962 Mar 15;38:241-6.
9
ELECTROLYTE EXCRETION BY SWEAT GLANDS AND KIDNEYS DURING SUPPRESSION OF ADRENAL CORTICOSTEROID ACTIVITY BY METHOPYRAPONE AND SPIRONOLACTONE.在甲吡酮和螺内酯抑制肾上腺皮质类固醇活性期间,汗腺和肾脏的电解质排泄情况
Am J Dis Child. 1965 Jan;109:2-8. doi: 10.1001/archpedi.1965.02090020004002.
10
The influence of mannitol on water and electrolyte excretion following trauma.甘露醇对创伤后水和电解质排泄的影响。
Surgery. 1962 Jul;52:188-94.

引用本文的文献

1
Prolonged Hypokalemia Following Metyrapone Treatment for Primary Bilateral Macronodular Adrenal Cortical Disease.美替拉酮治疗原发性双侧大结节性肾上腺皮质疾病后出现的持续性低钾血症
JCEM Case Rep. 2024 Feb 1;2(2):luae015. doi: 10.1210/jcemcr/luae015. eCollection 2024 Feb.
2
Does the Glucocorticoid Stress Response Make Toads More Toxic? An Experimental Study on the Regulation of Bufadienolide Toxin Synthesis.糖皮质激素应激反应会使蟾蜍毒性更强吗?关于蟾蜍二烯羟酸内酯毒素合成调控的实验研究。
Integr Org Biol. 2023 Jun 5;5(1):obad021. doi: 10.1093/iob/obad021. eCollection 2023.
3
Updates on the role of adrenal steroidogenesis inhibitors in Cushing's syndrome: a focus on novel therapies.

本文引用的文献

1
Colorimetric determination of substances containing the grouping -CH(2).CO- in urine extracts as an indication of androgen content.比色法测定尿提取物中含-CH(2).CO-基团的物质以指示雄激素含量。
Biochem J. 1938 Aug;32(8):1312-31. doi: 10.1042/bj0321312.
2
The determination of urinary steroids. I. The preparation of pigment-free extracts and a simplified procedure for the estimation of total 17-ketosteroids.尿甾体的测定。I. 无色素提取物的制备及总17-酮甾体测定的简化程序。
J Clin Endocrinol Metab. 1952 Jan;12(1):55-65. doi: 10.1210/jcem-12-1-55.
3
The isolation of a urinary metabolite of aldosterone and its use to measure the rate of secretion of aldosterone by the adrenal cortex of man.
库欣综合征中肾上腺类固醇生成抑制剂作用的最新进展:关注新疗法。
Pituitary. 2016 Dec;19(6):643-653. doi: 10.1007/s11102-016-0742-1.
4
Role of "old" pharmacological agents in the treatment of Cushing's syndrome.“老”药在库欣综合征治疗中的作用。
J Endocrinol Invest. 2016 Sep;39(9):957-65. doi: 10.1007/s40618-016-0462-4. Epub 2016 Apr 16.
5
Novel functionalized 5-(phenoxymethyl)-1,3-dioxane analogs exhibiting cytochrome P450 inhibition: a patent evaluation WO2015048311 (A1).具有细胞色素P450抑制活性的新型功能化5-(苯氧基甲基)-1,3-二氧六环类似物:专利评估WO2015048311(A1)
Expert Opin Ther Pat. 2016;26(1):139-47. doi: 10.1517/13543776.2016.1105217. Epub 2015 Oct 29.
6
Effectiveness of Metyrapone in Treating Cushing's Syndrome: A Retrospective Multicenter Study in 195 Patients.甲吡酮治疗库欣综合征的有效性:一项针对195例患者的回顾性多中心研究
J Clin Endocrinol Metab. 2015 Nov;100(11):4146-54. doi: 10.1210/jc.2015-2616. Epub 2015 Sep 9.
7
Aldosterone synthase inhibition: cardiorenal protection in animal disease models and translation of hormonal effects to human subjects.醛固酮合酶抑制:动物疾病模型中的心脏肾脏保护作用以及激素效应向人类受试者的转化
J Transl Med. 2014 Dec 10;12:340. doi: 10.1186/s12967-014-0340-9.
8
The Effect of an Adrenal Inhibitor (SU 4885) on Gastric Secretion in Dogs.一种肾上腺抑制剂(SU 4885)对犬胃分泌的影响。
Gut. 1960 Dec;1(4):345-50. doi: 10.1136/gut.1.4.345.
9
The pituitary and adrenal cortex in general medicine.普通医学中的垂体与肾上腺皮质。
Br Med J. 1960 Aug 27;2(5199):625-33. doi: 10.1136/bmj.2.5199.625.
10
[ELECTROLYTE ELIMINATION IN EXOGENOUS HEAT STRESS].[外源性热应激下的电解质排泄]
Klin Wochenschr. 1963 Dec 15;41:1181-6. doi: 10.1007/BF01480260.
醛固酮尿液代谢物的分离及其用于测定人肾上腺皮质醛固酮分泌率的用途。
Trans Assoc Am Physicians. 1958;71:225-35.
4
Aldosterone antagonists.醛固酮拮抗剂
AMA Arch Intern Med. 1958 Dec;102(6):998-1004. doi: 10.1001/archinte.1958.00260230144018.
5
Inhibition of adrenal steroid 11-oxygenation in the dog.犬肾上腺类固醇11-氧化作用的抑制
Science. 1958 Aug 29;128(3322):478-80. doi: 10.1126/science.128.3322.478-a.
6
Alterations of adrenal steroid patterns in man resulting from treatment with a chemical inhibitor of 11 beta-hydroxylation.用11β-羟化作用的化学抑制剂治疗导致的人体肾上腺类固醇模式的改变。
J Clin Endocrinol Metab. 1958 Aug;18(8):906-12. doi: 10.1210/jcem-18-8-906.
7
New amphenone analogs as adrenocortical inhibitors.新型安非酮类似物作为肾上腺皮质抑制剂。
Experientia. 1958 Apr 15;14(4):151-2. doi: 10.1007/BF02157133.
8
Plasma and urinary corticosteroids in the hypertensive form of congenital adrenal hyperplasia.先天性肾上腺增生症高血压型中的血浆和尿皮质类固醇
J Biol Chem. 1956 Nov;223(1):85-94.
9
Dual mechanism regulating adrenocortical function in man.人类肾上腺皮质功能的双重调节机制。
Am J Med. 1956 Sep;21(3):380-6. doi: 10.1016/0002-9343(56)90038-9.
10
The determination of 17,21-dihydroxy-20-ketosteroids in urine and plasma.尿液和血浆中17,21 - 二羟基 - 20 - 酮类固醇的测定
J Biol Chem. 1954 Oct;210(2):923-32.