Trowbridge H O, Stevens B H
Albert Einstein Medical Center, Philadelphia.
Curr Opin Dent. 1992 Jun;2:85-92.
The greatest cause of endodontic and periapical pathosis is microbial infection of the pulp. Most odontogenic infections are of a polymicrobial nature. With advances in anaerobic isolation and culturing techniques, much has been learned about the presence of pathogenic organisms such as Porphyromonas and Prevotella species (formerly classified as black-pigmented Bacteroides species) in infected root canals. This review provides a summary of recent developments in endodontic microbiology, virulence factors, and host defense systems as they relate to the pathogenesis of pulpal and periapical inflammatory lesions.
牙髓病和根尖周病的最大病因是牙髓的微生物感染。大多数牙源性感染具有多种微生物的特性。随着厌氧分离和培养技术的进步，人们对感染根管中诸如卟啉单胞菌属和普氏菌属（以前归类为产黑色素拟杆菌属）等致病生物体的存在有了更多了解。本文综述了牙髓病微生物学、毒力因子和宿主防御系统的最新进展，这些进展与牙髓和根尖周炎性病变的发病机制相关。
