McDonald T J, Krantis A, Clarke M, Mutt V, Jörnvall H E
Robarts Research Institute, London, Ontario, Canada.
Peptides. 1992 May-Jun;13(3):589-93. doi: 10.1016/0196-9781(92)90094-j.
The presence of a peptide capable of producing powerful contractions of rat small intestinal smooth muscle was detected in chromatographic fractions derived from porcine gastric corpus extracts. The pharmacological characteristics of this entity suggested that it might be galanin and on its purification to homogeneity, amino acid composition and sequence analysis demonstrated the identify of the gastric and intestinal forms of galanin. The presence of galanin in the gastric corpus tissue and its ability to affect gastric smooth muscle activity, gastrin release, and gastric acid secretion suggest potential important physiological roles for galanin in the stomach.
在从猪胃体提取物中获得的色谱馏分中检测到一种能够引起大鼠小肠平滑肌强烈收缩的肽。该物质的药理学特性表明它可能是甘丙肽，在将其纯化至同质后，氨基酸组成和序列分析证实了胃和肠形式的甘丙肽具有一致性。胃体组织中甘丙肽的存在及其影响胃平滑肌活动、胃泌素释放和胃酸分泌的能力表明甘丙肽在胃中可能具有重要的生理作用。
