[4-[2-(2,3-二甲基-4-[1-(4-异丁基苯基)乙氧基]苯氨基)苯氧基]丁酸钠（ONO-3805）及抗雄激素药物对大鼠附属生殖器官的作用]
[The effect of sodium-4-[2-(2,3-dimethyl-4-[1-(4- isobutylphenyl)ethoxy]benzolamino)phenoxy] butyrate (ONO-3805) and antiandrogenic agents on the rat accessory sex organs].
作者信息
Takahashi O, Imai K, Watanabe K, Nakazawa Y, Nakata S, Kurita M, Saito Y, Kubota H, Yamanaka H
机构信息
Department of Urology, Gunma University, School of Medicine.
出版信息
Hinyokika Kiyo. 1992 Mar;38(3):305-10.
The effects of sodium-4-[2-(2,3-dimethyl-4-[1-(4-isobutylphenyl) ethoxy]benzolamino)phenoxy]butyrate (ONO-3805), newly developed as a non-steroidal 5 alpha-reductase inhibitor, on rat accessory sex organs was compared with chlormadinone acetate (CMA) and non-steroidal antiandrogen, flutamide (FLU). ONO-3805 demonstrated excellent antiandrogenic activity which was similar to that of CMA in reducing the accessory sex organ weight. Moreover this agent did not show any significant effects on the serum testosterone level, but CMA and FLU changed it significantly. We previously reported the androgenic activity of antiandrogen (CMA, FLU, AA560, cyproterone acetate, medroxy progesterone, estrogen), but ONO-3805 is free of androgenic activity.
新开发的非甾体类5α-还原酶抑制剂4-[2-(2,3-二甲基-4-[1-(4-异丁基苯基)乙氧基]苯氨基)苯氧基]丁酸钠（ONO-3805）对大鼠附属生殖器官的作用，与醋酸氯地孕酮（CMA）和非甾体类抗雄激素药物氟他胺（FLU）进行了比较。ONO-3805表现出优异的抗雄激素活性，在减轻附属生殖器官重量方面与CMA相似。此外，该药物对血清睾酮水平没有任何显著影响，但CMA和FLU则使其发生了显著变化。我们之前报道过抗雄激素药物（CMA、FLU、AA560、醋酸环丙孕酮、甲羟孕酮、雌激素）的雄激素活性，但ONO-3805没有雄激素活性。
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