DUNCOMBE W G, McCOUBREY A
Br J Pharmacol Chemother. 1960 Jun;15(2):260-4. doi: 10.1111/j.1476-5381.1960.tb01241.x.
Bretylium (o-bromobenzylethyldimethylammonium) is a new type of hypotensive drug. It was estimated in extracts of human urine as the methyl orange complex. From 7 to 45% of a single oral dose was found in human urine within 9 hr. The [(14)C] labelled drug was used to investigate excretion by cats. A minor proportion of a subcutaneous dose was eliminated by cats in the faeces, probably after secretion into the bile. Most of the dose was excreted unchanged in the urine. No products of metabolism were found in either human or cat urine. The drug suffered negligible change when incubated with rat liver tissue in vitro.
溴苄铵（邻溴苄基乙基二甲基铵）是一种新型降压药。它在人尿提取物中以甲基橙络合物的形式进行测定。单次口服剂量的7%至45%在9小时内出现在人尿中。用[¹⁴C]标记的药物来研究猫的排泄情况。皮下注射剂量的一小部分被猫通过粪便排出，可能是在分泌到胆汁后。大部分剂量以原形经尿液排出。在人尿和猫尿中均未发现代谢产物。该药物在体外与大鼠肝组织孵育时变化可忽略不计。
