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[类风湿关节炎患者对金盐发生严重小肠结肠炎的毒性反应]

[Toxic reactions to gold salts with severe enterocolitis in a patient with rheumatoid arthritis].

作者信息

Gerster J C, de Kalbermatten A, de Peyer R, Toussaint M, Carrel J

出版信息

Schweiz Med Wochenschr. 1976 Nov 13;106(46):1606-8.

PMID:138187
Abstract

A case of severe enterocolitis which occurred on initiation of chrysotherapy for rheumatoid arthritis is reported. The patient, a male aged 50 years, suffered from dramatic diarrhea for several weeks. Biopsy specimens from the stomach, ileum and colon revealed signs of inflammation. Later, general toxicodermia, mouth ulcers, blood eosinophilia and asymptomatic proteinuria were observed. After several months all the side effects disappeared. The toxicodermia was the most persistent.

摘要

报告了1例类风湿关节炎金疗法起始时发生的严重小肠结肠炎病例。患者为一名50岁男性,数周来出现严重腹泻。胃、回肠和结肠的活检标本显示有炎症迹象。后来,观察到全身性中毒性表皮坏死松解症、口腔溃疡、血液嗜酸性粒细胞增多和无症状蛋白尿。几个月后,所有副作用均消失。中毒性表皮坏死松解症持续时间最长。

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