由于载体氯化作用，对三硝基苯基蛋白的三硝基苯基特异性体液反应增强。
Enhancement of trinitrophenyl-specific humoral response to TNP proteins as the result of carrier chlorination.
作者信息
Marcinkiewicz J, Olszowska E, Olszowski S, Zgliczynski J M
机构信息
Department of Immunology, Copernicus School of Medicine, Cracow, Poland.
出版信息
Immunology. 1992 Jul;76(3):385-8.
Abstract
Trinitrophenyl (TNP)-specific humoral response was tested after immunization with TNP-protein conjugates composed of either native proteins or proteins modified by chlorination. Significant enhancement of the hapten-specific response was observed as a result of carrier chlorination. This effect was dose dependent and affected mainly T-helper-cell activation. Since stimulated neutrophils chlorinate in vivo proteins, we propose that they take part in the induction phase of immune response by facilitation of antigen processing and/or presentation.
摘要
在用由天然蛋白质或经氯化修饰的蛋白质组成的三硝基苯基（TNP）-蛋白质缀合物免疫后，测试了TNP特异性体液反应。由于载体氯化，观察到半抗原特异性反应显著增强。这种效应呈剂量依赖性，主要影响T辅助细胞的激活。由于受刺激的中性粒细胞在体内使蛋白质氯化，我们提出它们通过促进抗原加工和/或呈递参与免疫反应的诱导阶段。
相似文献
1
2
3
Tolerance induction during ontogeny. II. Distinct unresponsive states in immature mice question the generality of clonal abortion.个体发育过程中的耐受性诱导。II. 未成熟小鼠中不同的无反应状态对克隆流产的普遍性提出质疑。
Eur J Immunol. 1983 Nov;13(11):928-35. doi: 10.1002/eji.1830131112.
4
T cell responses induced by the parenteral injection of antigen-modified syngeneic cells. I. Induction, characterization, and regulation of antigen-specific T helper cells involved in delayed-type hypersensitivity responses.经肠胃外注射抗原修饰的同基因细胞诱导的T细胞应答。I. 参与迟发型超敏反应的抗原特异性辅助性T细胞的诱导、特征及调节。
J Immunol. 1983 Jul;131(1):77-85.
5
6
Age-dependent isotype variation during secondary immune response in MRL/lpr mice producing autoanti-gamma-globulin antibodies.在产生自身抗γ-球蛋白抗体的MRL/lpr小鼠二次免疫应答过程中与年龄相关的同种型变异。
Eur J Immunol. 1985 Jul;15(7):718-22. doi: 10.1002/eji.1830150715.
7
Split unresponsiveness to the trinitrophenyl determinant. I. Manoeuvers which suppress either humoral or cell-mediated immune responses.对三硝基苯基决定簇的分裂无反应性。I. 抑制体液或细胞介导免疫反应的操作。
Eur J Immunol. 1977 Dec;7(12):855-60. doi: 10.1002/eji.1830071207.
8
9
10
Intracameral injection of antigen potentiates the production of antigen-specific T cell proteins in serum after the induction of delayed-type hypersensitivity.在前房内注射抗原可增强迟发型超敏反应诱导后血清中抗原特异性T细胞蛋白的产生。
Invest Ophthalmol Vis Sci. 1995 Jun;36(7):1470-6.
引用本文的文献
1
Secretions from hypochlorous acid-treated tumor cells delivered in a melittin hydrogel potentiate cancer immunotherapy.在蜂毒肽水凝胶中递送的经次氯酸处理的肿瘤细胞分泌物可增强癌症免疫疗法。
Bioact Mater. 2021 Jul 24;9:541-553. doi: 10.1016/j.bioactmat.2021.07.019. eCollection 2022 Mar.
2
Deciphering the Mechanisms of Improved Immunogenicity of Hypochlorous Acid-Treated Antigens in Anti-Cancer Dendritic Cell-Based Vaccines.解析次氯酸处理的抗原在基于抗癌树突状细胞的疫苗中免疫原性增强的机制
Vaccines (Basel). 2020 Jun 2;8(2):271. doi: 10.3390/vaccines8020271.
3
Personalized Dendritic Cell Vaccines-Recent Breakthroughs and Encouraging Clinical Results.个性化树突状细胞疫苗 - 最新突破和鼓舞人心的临床结果。
Front Immunol. 2019 Apr 11;10:766. doi: 10.3389/fimmu.2019.00766. eCollection 2019.
4
A Phase I vaccine trial using dendritic cells pulsed with autologous oxidized lysate for recurrent ovarian cancer.一项使用自体氧化裂解物致敏树突细胞的Ⅰ期疫苗试验，用于复发性卵巢癌。
J Transl Med. 2013 Jun 18;11:149. doi: 10.1186/1479-5876-11-149.
5
Whole tumor antigen vaccines.全肿瘤抗原疫苗。
Semin Immunol. 2010 Jun;22(3):132-43. doi: 10.1016/j.smim.2010.02.004. Epub 2010 Mar 30.
6
Hypochlorous acid enhances immunogenicity and uptake of allogeneic ovarian tumor cells by dendritic cells to cross-prime tumor-specific T cells.次氯酸可增强树突状细胞对同种异体卵巢肿瘤细胞的免疫原性及摄取，从而交叉启动肿瘤特异性T细胞。
Cancer Immunol Immunother. 2006 Nov;55(11):1384-95. doi: 10.1007/s00262-006-0127-9. Epub 2006 Feb 4.
7
Regulation of murine dendritic cell functions in vitro by taurine chloramine, a major product of the neutrophil myeloperoxidase-halide system.中性粒细胞髓过氧化物酶-卤化物系统的主要产物牛磺酸氯胺对小鼠树突状细胞功能的体外调节
Immunology. 1999 Nov;98(3):371-8. doi: 10.1046/j.1365-2567.1999.00905.x.
8
Oxidation of defined antigens allows protein unfolding and increases both proteolytic processing and exposes peptide epitopes which are recognized by specific T cells.特定抗原的氧化会使蛋白质展开，增加蛋白水解过程，并暴露出可被特定T细胞识别的肽表位。
Immunology. 1998 Nov;95(3):314-21. doi: 10.1046/j.1365-2567.1998.00618.x.
9
Modulation of antigen-specific T-cell activation in vitro by taurine chloramine.牛磺酸氯胺对体外抗原特异性T细胞活化的调节作用
Immunology. 1998 Jul;94(3):325-30. doi: 10.1046/j.1365-2567.1998.00515.x.
本文引用的文献
1
The carrier effect in the secondary response to hapten-protein conjugates. II. Cellular cooperation.对半抗原-蛋白质偶联物二次应答中的载体效应。II. 细胞协作。
Eur J Immunol. 1971 Jan;1(1):18-27. doi: 10.1002/eji.1830010104.
2
Antigen-presenting function of the macrophage.巨噬细胞的抗原呈递功能。
Annu Rev Immunol. 1984;2:395-428. doi: 10.1146/annurev.iy.02.040184.002143.
3
Induction of suppressor cells and cells producing antigen-specific suppressor factors by haptens bound to self carriers.与自身载体结合的半抗原诱导抑制细胞及产生抗原特异性抑制因子的细胞。
Immunobiology. 1980 Jan;156(4-5):400-9. doi: 10.1016/S0171-2985(80)80073-8.
4
The biochemistry and cell biology of antigen processing.抗原加工的生物化学与细胞生物学
Immunol Rev. 1988 Dec;106:33-58. doi: 10.1111/j.1600-065x.1988.tb00772.x.
5
Oxidation of lysine side-chains of elastin by the myeloperoxidase system and by stimulated human neutrophils.
Biochem Biophys Res Commun. 1986 Mar 13;135(2):451-7. doi: 10.1016/0006-291x(86)90015-x.
6
Two types of murine helper T cell clone. II. Delayed-type hypersensitivity is mediated by TH1 clones.两种小鼠辅助性T细胞克隆。II. 迟发型超敏反应由TH1克隆介导。
J Immunol. 1987 Jun 1;138(11):3688-94.
7
Enhancement of proteinase-mediated degradation of proteins modified by chlorination.
Int J Biochem. 1989;21(7):799-805. doi: 10.1016/0020-711x(89)90213-9.
8
T-lymphocyte recognition of antigen in association with gene products of the major histocompatibility complex.T淋巴细胞对与主要组织相容性复合体基因产物相关的抗原的识别。
Annu Rev Immunol. 1985;3:237-61. doi: 10.1146/annurev.iy.03.040185.001321.
9
Enhancement of immunogenic properties of ovalbumin as a result of its chlorination.卵清蛋白氯化导致其免疫原性增强。
Int J Biochem. 1991;23(12):1393-5. doi: 10.1016/0020-711x(91)90280-z.
10
Chlorinating ability of human phagocytosing leucocytes.人类吞噬性白细胞的氯化能力。
Eur J Biochem. 1975 Aug 1;56(1):157-62. doi: 10.1111/j.1432-1033.1975.tb02218.x.
Zotero 插件