Gruner S, Sehrt I, Müller G M, Zwirner A, Strunk D, Sönnichsen N
Department of Dermatology, Humboldt University, Berlin, Germany.
Agents Actions. 1992 Jul;36(3-4):207-11.
The influence of the ATPase inhibitors, lanthanum or cerium, on histamine release in basophils and mast cells was studied. Both compounds inhibited IgE- or A23187-induced histamine release. To exclude a general inhibition of calcium-dependent reactions in the cell, we tested the influence of these compounds on phagocytosis and superoxide production of neutrophil granulocytes. Phagocytosis of Candida albicans was inhibited partially, superoxide generation, measured by the INT test after stimulation with zymosan or aggregated gamma globulin, was not affected. Because of the inhibitory effect of lanthanum or cerium compounds on membrane ATPase and immunological function of epidermal Langerhans cells we propose that these compounds may be used in the treatment of atopic eczema, where both histamine-releasing mast cells and IgE-bearing Langerhans cell play a pathogenetically important role.
研究了ATP酶抑制剂镧或铈对嗜碱性粒细胞和肥大细胞中组胺释放的影响。这两种化合物均抑制IgE或A23187诱导的组胺释放。为排除对细胞中钙依赖性反应的普遍抑制作用，我们测试了这些化合物对中性粒细胞吞噬作用和超氧化物产生的影响。白色念珠菌的吞噬作用受到部分抑制，在用酵母聚糖或聚集的γ球蛋白刺激后通过INT试验测定的超氧化物生成未受影响。由于镧或铈化合物对膜ATP酶和表皮朗格汉斯细胞免疫功能的抑制作用，我们提出这些化合物可用于治疗特应性湿疹，其中组胺释放肥大细胞和携带IgE的朗格汉斯细胞在发病机制中都起着重要作用。
