Aoyagi K, Oomura Y, Shimizu N
Department of Physiology, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Behav Brain Res. 1992 Aug 10;49(2):205-12. doi: 10.1016/s0166-4328(05)80166-4.
To further investigate the activity of serotonin neurons in relation to feeding behavior, the metabolic activity of the serotonergic system and single neuron activity changes in the lateral hypothalamic area (LHA) were investigated concurrently in freely behaving rats. The extracellular concentration of 5-hydroxyindoleacetic acid (5-HIAA), a metabolic product of serotonin in the LHA, began to increase concomitantly with the early stage of nocturnal eating. The increased 5-HIAA returned to the basal level within 3 or 4 h. In conjunction with the increase in serotonin metabolism, activity of 12 out of 30 LHA neurons (40%) increased, whereas it decreased in 7 (23%), and in 11 (37%) it showed no change. An intracerebroventricular injection of lisuride suppressed the increased activity in 7 of the 12 neurons, but had no effect on the others. These results suggest that the concurrent increase in serotonin metabolism and neuron activity changes in the LHA may occur in the early portion of the nocturnal eating period, and may be important in controlling feeding behavior.
为了进一步研究血清素神经元与进食行为相关的活动，我们在自由活动的大鼠中同时研究了血清素能系统的代谢活性和下丘脑外侧区（LHA）的单神经元活动变化。LHA中血清素的代谢产物5-羟吲哚乙酸（5-HIAA）的细胞外浓度在夜间进食早期开始同时增加。增加的5-HIAA在3或4小时内恢复到基础水平。与血清素代谢增加同时，30个LHA神经元中的12个（40%）的活动增加，而7个（23%）的活动减少，11个（37%）没有变化。脑室内注射利苏瑞得抑制了12个神经元中7个的活动增加，但对其他神经元没有影响。这些结果表明，LHA中血清素代谢和神经元活动变化的同时增加可能发生在夜间进食期的早期部分，并且可能在控制进食行为中起重要作用。
