• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

The metabotropic excitatory amino acid receptor agonist 1S,3R-ACPD selectively potentiates N-methyl-D-aspartate-induced brain injury.

作者信息

McDonald J W, Schoepp D D

机构信息

CNS Research, Eli Lilly and Company, Indianapolis, IN 46285.

出版信息

Eur J Pharmacol. 1992 May 14;215(2-3):353-4. doi: 10.1016/0014-2999(92)90058-c.

DOI:10.1016/0014-2999(92)90058-c
PMID:1383003
Abstract

The role of metabotropic type excitatory amino acid receptors in brain injury was assessed using the selective metabotropic receptor agonist, (1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid (1S,3R-ACPD). Intrastriatal stereotaxic injection of 1S,3R-ACPD (250 nmol) in PND 7 rats produced little brain injury as assessed by hemispheric weight disparities. However, 1S,3R-ACPD markedly potentiated N-methyl-D-aspartate (NMDA)-, but not alpha-amino-3-hydroxy-5-methyl-4-isoxazoleproprionic acid (AMPA)-, mediated brain injury. This effect was stereoselective since the inactive metabotropic agonist, 1R,3S-ACPD, did not potentiate NMDA toxicity.

摘要

相似文献

1
The metabotropic excitatory amino acid receptor agonist 1S,3R-ACPD selectively potentiates N-methyl-D-aspartate-induced brain injury.
Eur J Pharmacol. 1992 May 14;215(2-3):353-4. doi: 10.1016/0014-2999(92)90058-c.
2
Comparison of (1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid (1S,3R-ACPD)- and 1R,3S-ACPD-stimulated brain phosphoinositide hydrolysis.(1S,3R)-1-氨基环戊烷-1,3-二羧酸（1S,3R-ACPD）和1R,3S-ACPD刺激的脑磷酸肌醇水解的比较。
Eur J Pharmacol. 1991 Aug 14;207(4):351-3. doi: 10.1016/0922-4106(91)90010-f.
3
Seizures and brain injury in neonatal rats induced by 1S,3R-ACPD, a metabotropic glutamate receptor agonist.代谢型谷氨酸受体激动剂1S,3R-ACPD诱导新生大鼠癫痫发作和脑损伤。
J Neurosci. 1993 Oct;13(10):4445-55. doi: 10.1523/JNEUROSCI.13-10-04445.1993.
4
Pharmacological characterization of metabotropic glutamate receptors potentiating NMDA responses in mouse cortical wedge preparations.代谢型谷氨酸受体增强小鼠皮质楔形标本中NMDA反应的药理学特征
Br J Pharmacol. 1996 Jul;118(6):1530-6. doi: 10.1111/j.1476-5381.1996.tb15570.x.
5
Intrastriatal injection of a selective metabotropic excitatory amino acid receptor agonist induces contralateral turning in the rat.纹状体内注射选择性促代谢型兴奋性氨基酸受体激动剂可诱导大鼠出现对侧旋转。
J Pharmacol Exp Ther. 1991 Dec;259(3):1366-70.
6
Modulation of AMPA and NMDA responses in rat spinal dorsal horn neurons by trans-1-aminocyclopentane-1,3-dicarboxylic acid.反式-1-氨基环戊烷-1,3-二羧酸对大鼠脊髓背角神经元中AMPA和NMDA反应的调节作用
Neurosci Lett. 1992 Sep 14;144(1-2):180-4. doi: 10.1016/0304-3940(92)90745-s.
7
Metabotropic glutamate receptors potentiate ionotropic glutamate responses in the rat dorsal horn.代谢型谷氨酸受体增强大鼠背角中的离子型谷氨酸反应。
Mol Pharmacol. 1992 Aug;42(2):192-6.
8
(R,S)-alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptors mediate a calcium-dependent inhibition of the metabotropic glutamate receptor-stimulated formation of inositol 1,4,5-trisphosphate.（R，S）-α-氨基-3-羟基-5-甲基异恶唑-4-丙酸（AMPA）受体介导对代谢型谷氨酸受体刺激的肌醇1,4,5-三磷酸形成的钙依赖性抑制。
J Neurochem. 1993 May;60(5):1739-45. doi: 10.1111/j.1471-4159.1993.tb13398.x.
9
Pharmacology of metabotropic glutamate receptor-mediated enhancement of responses to excitatory and inhibitory amino acids on rat spinal neurones in vivo.代谢型谷氨酸受体介导增强大鼠脊髓神经元对兴奋性和抑制性氨基酸体内反应的药理学研究
Neuropharmacology. 1995 Aug;34(8):1015-23. doi: 10.1016/0028-3908(95)00046-9.
10
Actions of two new antagonists showing selectivity for different sub-types of metabotropic glutamate receptor in the neonatal rat spinal cord.两种新型拮抗剂对新生大鼠脊髓中不同亚型代谢型谷氨酸受体的作用表现出选择性。
Br J Pharmacol. 1994 Jul;112(3):809-16. doi: 10.1111/j.1476-5381.1994.tb13151.x.

引用本文的文献

1
Sigma receptors [σRs]: biology in normal and diseased states.西格玛受体[σRs]：正常及疾病状态下的生物学特性
J Recept Signal Transduct Res. 2016 Aug;36(4):327-388. doi: 10.3109/10799893.2015.1015737. Epub 2015 Jun 9.
2
An analog of thyrotropin-releasing hormone (TRH) is neuroprotective against glutamate-induced toxicity in fetal rat hippocampal neurons in vitro.促甲状腺激素释放激素（TRH）的一种类似物在体外对胎鼠海马神经元中谷氨酸诱导的毒性具有神经保护作用。
Brain Res. 2007 Jan 12;1128(1):79-85. doi: 10.1016/j.brainres.2006.10.047. Epub 2006 Nov 27.
3
The role of group I metabotropic glutamate receptors in neuronal excitotoxicity in Alzheimer's disease.
I 型代谢型谷氨酸受体在阿尔茨海默病神经元兴奋性毒性中的作用。
Neurotox Res. 2005;7(1-2):125-41. doi: 10.1007/BF03033782.
4
Effects of metabotropic glutamate receptor stimulation on cerebral O2 consumption and blood flow during focal cerebral ischemia in rats.代谢型谷氨酸受体刺激对大鼠局灶性脑缺血期间脑氧消耗和血流的影响。
Neurochem Res. 2003 Dec;28(12):1799-804. doi: 10.1023/a:1026159422237.
5
Involvement of metabotropic glutamate receptors in ischemia-induced taurine release in the developing and adult hippocampus.代谢型谷氨酸受体参与发育中和成年海马体中缺血诱导的牛磺酸释放。
Neurochem Res. 2000 Aug;25(8):1067-72. doi: 10.1023/a:1007677610714.
6
Tyrosine kinase inhibitors enhance a Ca(2+)-activated K+ current (IAHP) and reduce IAHP suppression by a metabotropic glutamate receptor agonist in rat dentate granule neurones.酪氨酸激酶抑制剂可增强大鼠齿状颗粒神经元中一种钙激活钾电流（IAHP），并减少代谢型谷氨酸受体激动剂对IAHP的抑制作用。
J Physiol. 1996 Oct 1;496 ( Pt 1)(Pt 1):139-44. doi: 10.1113/jphysiol.1996.sp021671.
7
Activation of metabotropic glutamate receptor subtype mGluR1 contributes to post-traumatic neuronal injury.代谢型谷氨酸受体亚型mGluR1的激活会导致创伤后神经元损伤。
J Neurosci. 1996 Oct 1;16(19):6012-20. doi: 10.1523/JNEUROSCI.16-19-06012.1996.
8
Regulation of N-methyl-D-aspartate-induced toxicity in the neostriatum: a role for metabotropic glutamate receptors?新纹状体中N-甲基-D-天冬氨酸诱导毒性的调节：代谢型谷氨酸受体的作用？
Proc Natl Acad Sci U S A. 1996 Feb 6;93(3):1200-4. doi: 10.1073/pnas.93.3.1200.