Tomomura M, Nakagawa K, Saheki T
Department of Biochemistry, Faculty of Medicine, Kagoshima University, Japan.
FEBS Lett. 1992 Oct 12;311(1):63-6. doi: 10.1016/0014-5793(92)81368-v.
We determined the mRNA levels of c-jun and c-fos in the liver of C3H-H-2 degrees jvs mice. Both were higher in jvs mice than in normal mice. The level of c-jun mRNA increased gradually after birth, but in the control mice there was almost no change. In addition, alpha-fetoprotein and aldolase A mRNA levels were also higher than in normal littermates. These results suggest that the pattern of the gene expression in jvs mice partly resembles the one that occurs in undifferentiated hepatocytes and/or hepatocellular carcinoma.
我们测定了C3H-H-2°jvs小鼠肝脏中c-jun和c-fos的mRNA水平。两者在jvs小鼠中均高于正常小鼠。c-jun mRNA水平在出生后逐渐升高，但对照小鼠中几乎没有变化。此外，甲胎蛋白和醛缩酶A的mRNA水平也高于正常同窝小鼠。这些结果表明，jvs小鼠的基因表达模式部分类似于未分化肝细胞和/或肝细胞癌中的基因表达模式。
