• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

TIBO derivatives: a new class of highly potent and specific inhibitors of HIV-1 replication.

作者信息

Pauwels R, Andries K, Debyser Z, Kukla M, Schols D, Desmyter J, De Clercq E, Janssen P A

机构信息

Rega Institute for Medical Research, Katholieke Universiteit Leuven, Belgium.

出版信息

Biochem Soc Trans. 1992 May;20(2):509-12. doi: 10.1042/bst0200509.

DOI:10.1042/bst0200509
PMID:1383063
Abstract
摘要

相似文献

1
TIBO derivatives: a new class of highly potent and specific inhibitors of HIV-1 replication.替博衍生物:一类新型的高效且特异性的HIV-1复制抑制剂。
Biochem Soc Trans. 1992 May;20(2):509-12. doi: 10.1042/bst0200509.
2
Kinetics of inhibition of endogenous human immunodeficiency virus type 1 reverse transcription by 2',3'-dideoxynucleoside 5'-triphosphate, tetrahydroimidazo-[4,5,1-jk][1,4]-benzodiazepin-2(1H)-thion e, and 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine derivatives.2',3'-双脱氧核苷5'-三磷酸、四氢咪唑并-[4,5,1-jk][1,4]-苯并二氮杂卓-2(1H)-硫酮和1-[(2-羟基乙氧基)甲基]-6-(苯硫基)胸腺嘧啶衍生物对人内源性1型免疫缺陷病毒逆转录的抑制动力学
J Biol Chem. 1992 Jun 15;267(17):11769-76.
3
Differential antiviral activity of two TIBO derivatives against the human immunodeficiency and murine leukemia viruses alone and in combination with other anti-HIV agents.两种TIBO衍生物单独及与其他抗HIV药物联合使用时对人类免疫缺陷病毒和鼠白血病病毒的抗病毒活性差异。
AIDS Res Hum Retroviruses. 1993 Nov;9(11):1097-106. doi: 10.1089/aid.1993.9.1097.
4
New tetrahydroimidazo[4,5,1-jk][1,4]-benzodiazepin-2(1H)-one and -thione derivatives are potent inhibitors of human immunodeficiency virus type 1 replication and are synergistic with 2',3'-dideoxynucleoside analogs.新型四氢咪唑并[4,5,1-jk][1,4]-苯并二氮杂卓-2(1H)-酮和-硫酮衍生物是1型人类免疫缺陷病毒复制的有效抑制剂,并且与2',3'-双脱氧核苷类似物具有协同作用。
Antimicrob Agents Chemother. 1994 Dec;38(12):2863-70. doi: 10.1128/AAC.38.12.2863.
5
An antiviral target on reverse transcriptase of human immunodeficiency virus type 1 revealed by tetrahydroimidazo-[4,5,1-jk] [1,4]benzodiazepin-2 (1H)-one and -thione derivatives.四氢咪唑并-[4,5,1-jk][1,4]苯并二氮杂卓-2(1H)-酮和-硫酮衍生物揭示的1型人类免疫缺陷病毒逆转录酶上的抗病毒靶点
Proc Natl Acad Sci U S A. 1991 Feb 15;88(4):1451-5. doi: 10.1073/pnas.88.4.1451.
6
Potent and selective inhibition of HIV-1 replication in vitro by a novel series of TIBO derivatives.一系列新型替博(TIBO)衍生物在体外对HIV-1复制具有强效且选择性的抑制作用。
Nature. 1990 Feb 1;343(6257):470-4. doi: 10.1038/343470a0.
7
Chemotherapy of the acquired immune deficiency syndrome (AIDS): non-nucleoside inhibitors of the human immunodeficiency virus type 1 reverse transcriptase.获得性免疫缺陷综合征(艾滋病)的化疗:1型人类免疫缺陷病毒逆转录酶的非核苷抑制剂
Int J Immunopharmacol. 1991;13 Suppl 1:83-9. doi: 10.1016/0192-0561(91)90129-u.
8
Quantitative structure-activity relationship studies on anti-HIV-1 TIBO derivatives as inhibitors of viral reverse transcriptase.作为病毒逆转录酶抑制剂的抗HIV-1 TIBO衍生物的定量构效关系研究。
J Enzyme Inhib. 1996 Aug;11(1):23-32. doi: 10.3109/14756369609038219.
9
Resistance of human immunodeficiency virus type 1 reverse transcriptase to TIBO derivatives induced by site-directed mutagenesis.1型人类免疫缺陷病毒逆转录酶对定点诱变诱导的替博韦衍生物的耐药性。
Virology. 1992 Jun;188(2):900-4. doi: 10.1016/0042-6822(92)90550-9.
10
A single conservative amino acid substitution in the reverse transcriptase of human immunodeficiency virus-1 confers resistance to (+)-(5S)-4,5,6,7-tetrahydro-5-methyl-6-(3-methyl-2-butenyl)imidazo[4,5, 1- jk][1,4]benzodiazepin-2(1H)-thione (TIBO R82150).人类免疫缺陷病毒1型逆转录酶中的单个保守氨基酸取代赋予了对(+)-(5S)-4,5,6,7-四氢-5-甲基-6-(3-甲基-2-丁烯基)咪唑并[4,5,1-jk][1,4]苯并二氮杂卓-2(1H)-硫酮(TIBO R82150)的抗性。
Mol Pharmacol. 1993 Jan;43(1):11-6.

引用本文的文献

1
Inhibition of dengue virus polymerase by blocking of the RNA tunnel.通过阻断 RNA 隧道抑制登革热病毒聚合酶。
J Virol. 2010 Jun;84(11):5678-86. doi: 10.1128/JVI.02451-09. Epub 2010 Mar 17.