用从同种脑提取的致脑炎蛋白抑制豚鼠实验性“过敏性”脑脊髓炎
Suppression of experimental "allergic" encephalomyelitis in guinea pigs by encephalitogenic proteins extracted from homologous brain.
作者信息
SHAW C M, FAHLBERG W J, KIES M W, ALVORD E C
出版信息
J Exp Med. 1960 Feb 1;111(2):171-80. doi: 10.1084/jem.111.2.171.
Abstract
The intradermal injection of aqueous solutions of certain homologous neural proteins will suppress the encephalomyelitis which is induced in guinea pigs by the previous injection of whole homologous brain with Freund's adjuvants. These neural proteins extracted by dilute acid from defatted guinea pig brain are themselves highly encephalitogenic when injected with adjuvants, but the specificity of this suppression for encephalitogenic as compared to non-encephalitogenic extracts remains to be proven. Suppression is probably not due to a non-specific stress reaction, as indicated by the absence of suppression by intradermal injections of alcohol and by statistically insignificant and inconstant effects of similar injections of tuberculin.
摘要
向豚鼠皮内注射某些同源神经蛋白的水溶液，可抑制此前用弗氏佐剂注射全同源脑所诱发的脑脊髓炎。这些从脱脂豚鼠脑中用稀酸提取的神经蛋白，在与佐剂一起注射时本身具有高度致脑炎作用，但与非致脑炎提取物相比，这种抑制作用对致脑炎物质的特异性仍有待证实。抑制作用可能并非由于非特异性应激反应，皮内注射酒精未产生抑制作用以及类似注射结核菌素的作用在统计学上无显著意义且不稳定，均表明了这一点。
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