Brown A M
Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston.
Hosp Pract (Off Ed). 1992 Oct 15;27(10):125-30, 132. doi: 10.1080/21548331.1992.11705513.
Molecular structure-function studies have identified the two key regions--the voltage sensor and pore--of the sodium and potassium channels responsible for the action potential in nerve axon. Mutational analysis has focused on the amino acids that are most important in each region. Similar studies in myocytes and nerve cell bodies are now being pursued.
分子结构功能研究已经确定了钠通道和钾通道中负责神经轴突动作电位的两个关键区域——电压传感器和孔道。突变分析聚焦于每个区域中最重要的氨基酸。目前正在对心肌细胞和神经细胞体进行类似的研究。
