Steinberg D, Beeman D, Bowen W H
Department of Dental Research, University of Rochester, New York 14642.
J Dent Res. 1992 Nov;71(11):1797-802. doi: 10.1177/00220345920710110601.
The prolonged retention of an effective chemotherapeutic agent on oral surfaces and in dental plaque aids in plaque control. The objective of this study was to investigate interactions between delmopinol, a morpholinoethanol derivative, and experimental pellicle. Hydroxyapatite beads were coated with different constituents of pellicle (e.g., saliva, carbohydrates, cell-free enzymes, and bacteria). Delmopinol demonstrated a higher affinity for saliva-coated hydroxyapatite (sHA) and for experimental pellicle coated with in situ-synthesized glucans than for untreated hydroxyapatite. High-molecular-weight (MW) dextran but not low-MW dextran interfered with the adsorption of delmopinol to sHA. Delmopinol did not compete with dextran for the same binding sites on sHA, nor did it compete with saliva for the same binding sites on untreated hydroxyapatite. Delmopinol inhibited the activity of cell-free fructosyltransferase adsorbed onto sHA. In addition, synthesis of glucans by Streptococcus mutans adsorbed onto sHA was significantly reduced in the presence of delmopinol.
一种有效的化疗药物在口腔表面和牙菌斑中的长时间留存有助于控制牙菌斑。本研究的目的是调查吗啉乙醇衍生物地莫匹醇与实验性薄膜之间的相互作用。用薄膜的不同成分（如唾液、碳水化合物、无细胞酶和细菌）包被羟基磷灰石珠。与未处理的羟基磷灰石相比，地莫匹醇对唾液包被的羟基磷灰石（sHA）以及原位合成葡聚糖包被的实验性薄膜具有更高的亲和力。高分子量（MW）葡聚糖而非低分子量葡聚糖会干扰地莫匹醇吸附到sHA上。地莫匹醇与葡聚糖在sHA上不存在相同结合位点的竞争，它与唾液在未处理的羟基磷灰石上也不存在相同结合位点的竞争。地莫匹醇抑制吸附在sHA上的无细胞果糖基转移酶的活性。此外，在存在地莫匹醇的情况下，吸附在sHA上的变形链球菌合成葡聚糖的量显著减少。
