TASKER P, SIMON S E, JOHNSTONE B M, SHANKLY K H, SHAW F H
J Gen Physiol. 1959 Sep;43(1):39-53. doi: 10.1085/jgp.43.1.39.
A survey has been made of the amount of muscle water available to inulin, sucrose, and radioiodinated human serum albumin (RISA). The percentage spaces available to the three molecules are of the same order of magnitude, but the sucrose space > inulin space > albumin space. The kinetics of influx and efflux of RISA have been studied, and it appears that a small part of the albumin may be adsorbed in the extracellular phase. Nevertheless the albumin space would appear to give the best index of the extracellular volume. The scatter in values found for the extracellular space by all methods is very great, ranging from 8 to 40 per cent and renders invalid the use of a mean value for the calculation of intracellular concentrations. The variation within paired muscles is less than between pairs, provided the tissue has undergone no volume change. Increase in total muscle volume when the muscle is placed in a hypotonic solution leads to a decrease in the size of the extracellular space.
对菊粉、蔗糖和放射性碘化人血清白蛋白（RISA）可利用的肌肉水量进行了一项调查。这三种分子的可用空间百分比处于相同的数量级，但蔗糖空间＞菊粉空间＞白蛋白空间。对RISA的流入和流出动力学进行了研究，似乎有一小部分白蛋白可能吸附在细胞外相中。然而，白蛋白空间似乎能给出细胞外体积的最佳指标。通过所有方法测得的细胞外空间值的离散度非常大，范围从8%到40%，因此使用平均值来计算细胞内浓度是无效的。如果组织没有体积变化，配对肌肉内的变化小于配对之间的变化。当肌肉置于低渗溶液中时，肌肉总体积的增加会导致细胞外空间大小的减小。
