Bharati S, Scheinman M, Lev M
Congenital Heart and Conduction System Center, Oak Lawn, Illinois 60463.
Pacing Clin Electrophysiol. 1992 Sep;15(9):1291-9. doi: 10.1111/j.1540-8159.1992.tb03140.x.
This is a detailed pathological examination of the heart including the conduction system (CS) from a 64-year-old male who had catheter ablation of the atrioventricular (AV) junction for intractable atrial fibrillation. This is the world's first human who had this procedure, and who survived 3 years and 8 months, and later died of congestive heart failure. Pathologically, the heart was hypertrophied and enlarged. Histologically, there were chronic inflammatory cells, marked fatty metamorphosis with fibrosis of the atria, the approaches to the AV node, and the AV node, with almost isolation of the node from the atria, and considerable fibrosis of the bundle and bundle branches. In addition, there was fibrosis of the summit of the ventricular septum with chronic inflammatory cells. These represent the sequelae of the ablation procedures. It is not known how much of the pathological findings contributed to the cardiac hypertrophy and impairment of cardiac function.
这是对一名64岁男性心脏进行的详细病理检查，包括传导系统（CS）。该男性因顽固性心房颤动接受了房室（AV）结导管消融术。这是世界上首例接受该手术且存活了3年零8个月的人，后来死于充血性心力衰竭。病理检查显示，心脏肥厚且增大。组织学检查发现，存在慢性炎症细胞，心房、房室结附近及房室结有明显的脂肪变性伴纤维化，房室结几乎与心房分离，束支和束分支有相当程度的纤维化。此外，室间隔顶部有纤维化并伴有慢性炎症细胞。这些表现为消融手术的后遗症。尚不清楚这些病理结果在多大程度上导致了心脏肥大和心功能损害。
