Menéndez J A, Atrens D M, Leibowitz S F
Department of Psychology, University of Sydney, NSW, Australia.
Peptides. 1992 Mar-Apr;13(2):323-7. doi: 10.1016/0196-9781(92)90116-k.
The metabolic effects of single injections of galanin into the paraventricular nucleus of the hypothalamus (PVN) were investigated in an open-circuit calorimeter. Wistar rats were tested, with no food available during the tests. In the dose range of 0.03-0.3 nmol, galanin produced a very short-latency (approximately 2 minutes) and short-lasting (approximately 15 minutes) reduction in energy expenditure. Since the same doses had no effect on respiratory quotient or locomotor activity, the metabolic effect is not secondary to changes in energy substrate utilization or locomotor activity. This antithermogenic effect complements the eating stimulatory action of PVN galanin, and together these phenomena suggest a role for galanin as an anabolic neuropeptide. The similarity of galanin's effects to those of norepinephrine, with which it coexists in PVN nerve endings, further suggests the involvement of this amine and the PVN alpha2-noradrenergic system in galanin's mechanism of action.
在下丘脑室旁核（PVN）单次注射甘丙肽的代谢效应，是在开路式热量计中进行研究的。选用Wistar大鼠进行测试，测试期间不给食物。在0.03 - 0.3纳摩尔的剂量范围内，甘丙肽使能量消耗出现非常短的潜伏期（约2分钟）和短暂的持续时间（约15分钟）下降。由于相同剂量对呼吸商或运动活动没有影响，所以这种代谢效应并非继发于能量底物利用或运动活动的变化。这种抗产热效应补充了PVN甘丙肽的进食刺激作用，这些现象共同表明甘丙肽作为一种合成代谢神经肽发挥作用。甘丙肽的效应与去甲肾上腺素的效应相似，二者共存于PVN神经末梢，这进一步提示该胺类物质和PVNα2 - 去甲肾上腺素能系统参与了甘丙肽的作用机制。
